Chemically-sensitive sensor array calibration circuitry
First Claim
1. An apparatus, comprising:
- an array of sensors arranged in rows and columns, a row including a plurality of sensors, each sensor in the plurality including a chemically-sensitive field effect transistor (chemFET) configured to produce a signal on an output in response to a row select signal; and
a plurality of column output circuits coupled to the outputs of corresponding columns of sensors in the array, and coupled to a circuit to apply a reference voltage to the column output circuits during a calibration operation, wherein a column output circuit in the plurality includes a column sample and hold capacitor directly connected to an input node of the column output circuit.
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Accused Products
Abstract
Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
464 Citations
18 Claims
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1. An apparatus, comprising:
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an array of sensors arranged in rows and columns, a row including a plurality of sensors, each sensor in the plurality including a chemically-sensitive field effect transistor (chemFET) configured to produce a signal on an output in response to a row select signal; and a plurality of column output circuits coupled to the outputs of corresponding columns of sensors in the array, and coupled to a circuit to apply a reference voltage to the column output circuits during a calibration operation, wherein a column output circuit in the plurality includes a column sample and hold capacitor directly connected to an input node of the column output circuit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus, comprising:
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an array of chemically sensitive sensors with corresponding chemical sample wells, each sensor in the plurality including a floating gate structure coupled to a corresponding chemical sample well; circuitry to provide at least one reference voltage; an output circuit directly connected to a sample and hold capacitor; and at least one switch to selectively connect an output of a sensor in the array and the reference voltage to the output circuit. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification