System and method for image based physiological monitoring of cardiovascular function
First Claim
1. A computer implemented method for real time monitoring of cardiac function, the method performed by the computer comprising the steps of:
- selecting a plane through a heart from which to acquire heart function data;
locating a center of a chamber of said heart;
acquiring a sequence of 2D magnetic resonance (MR) images from said plane over one or more cardiac cycles with a time resolution at least one order of magnitude less than the cardiac rate, wherein each of said images comprises a plurality of intensities defined on a domain of points on a 2D grid;
projecting a plurality of beams from said chamber center through each MR image as each MR image is acquired, each beam comprising a substantially collinear subset of points in said image;
sampling image intensities along periodically spaced points of each beam in each MR image;
obtaining image intensity in real-time as a function of time at corresponding beam points across the acquired MR images, wherein a time resolution of the image intensity function is at least that of the sequence of the 2D MR images;
detecting endocardial contours from said image intensity functions sampled at periodically spaced points of each of the plurality of beams in each MR image;
calculating distances between said detected endocardial contours, wherein the maximum distances as a function of time in each projection beam are taken as the end-diastolic (ED) diameter, and the minimum distances are taken as the end-systolic (ES) diameter; and
using said image intensity time function along each said beam to detect changes in values of a physiological parameter over time.
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Abstract
A method for real time monitoring of cardiac function includes defining a plurality of planes through a heart from which to acquire heart imaging data, acquiring a sequence of 2-dimensional images from said selected planes, wherein each said image comprises a plurality of intensities defined on a domain of points on a 2D grid, selecting one or more of said sequence of images to provide imaging data for monitoring heart function, wherein said remaining unselected images are adapted for diagnostic purposes, and repeating said steps of acquiring a sequence of 2-dimensional images from said selected planes and selecting one or more of said sequence of images for monitoring heart function, wherein a time sequence of images is obtained, alternating between images for monitoring heart function and images for diagnostic purposes.
17 Citations
28 Claims
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1. A computer implemented method for real time monitoring of cardiac function, the method performed by the computer comprising the steps of:
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selecting a plane through a heart from which to acquire heart function data; locating a center of a chamber of said heart; acquiring a sequence of 2D magnetic resonance (MR) images from said plane over one or more cardiac cycles with a time resolution at least one order of magnitude less than the cardiac rate, wherein each of said images comprises a plurality of intensities defined on a domain of points on a 2D grid; projecting a plurality of beams from said chamber center through each MR image as each MR image is acquired, each beam comprising a substantially collinear subset of points in said image; sampling image intensities along periodically spaced points of each beam in each MR image; obtaining image intensity in real-time as a function of time at corresponding beam points across the acquired MR images, wherein a time resolution of the image intensity function is at least that of the sequence of the 2D MR images; detecting endocardial contours from said image intensity functions sampled at periodically spaced points of each of the plurality of beams in each MR image; calculating distances between said detected endocardial contours, wherein the maximum distances as a function of time in each projection beam are taken as the end-diastolic (ED) diameter, and the minimum distances are taken as the end-systolic (ES) diameter; and using said image intensity time function along each said beam to detect changes in values of a physiological parameter over time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A computer implemented method for real time monitoring of cardiac function during an image guided interventional procedure, the method performed by the computer comprising the steps of:
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defining a plurality of mutually orthogonal planes through a heart from which to acquire heart imaging data for acquiring a time series of 2-dimensional images from said selected planes, wherein each said image comprises a plurality of intensities defined on a domain of points on a 2D grid; selecting a subset of said time series of images to provide imaging data for monitoring heart function, wherein said selected subset of images are to be acquired from a same plane, wherein said remaining unselected images are acquired from a different plane and are adapted for diagnostic purposes; acquiring said time series of images over one or more heart cycles, wherein an image is acquired from each of the plurality of planes at each acquisition time, alternating between acquiring images for monitoring heart function and acquiring images for diagnostic purposes, wherein every nth image acquired during each heart cycle is acquired for monitoring, wherein n is greater than or equal to 2, wherein image intensities are extracted from corresponding points across the acquired monitoring images as each monitoring image is acquired to define said image intensities as a function of time; and using said image intensity time functions along each said beam to detect changes in values of a physiological parameter over time. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A program storage device readable by a computer, tangibly embodying a non-transitory program of instructions executable by the computer to perform the method steps for real time monitoring of cardiac function, said method comprising the steps of:
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selecting a plane through a heart from which to acquire heart function data; locating a center of a chamber of said heart; acquiring a sequence of 2D magnetic resonance (MR) images from said plane over one or more cardiac cycles with a time resolution at least one order of magnitude less than the cardiac rate, wherein each of said images comprises a plurality of intensities defined on a domain of points on a 2D grid; projecting a plurality of beams from said chamber center through each MR image as each MR image is acquired, each beam comprising a substantially collinear subset of points in said image; sampling image intensities along periodically spaced points of each beam in each MR image; obtaining image intensity in real-time as a function of time at corresponding beam points across the acquired MR images, wherein a time resolution of the image intensity function is at least that of the sequence of the 2D MR images; detecting endocardial contours from said image intensity functions sampled at periodically spaced points of each of the plurality of beams in each MR image; calculating distances between said detected endocardial contours, wherein the maximum distances as a function of time in each projection beam are taken as the end-diastolic (ED) diameter, and the minimum distances are taken as the end-systolic (ES) diameter; and using said image intensity time function along each said beam to detect changes in values of a physiological parameter over time. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification