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Metabolic phenotyping

  • US 8,577,617 B2
  • Filed: 09/19/2008
  • Issued: 11/05/2013
  • Est. Priority Date: 06/14/2002
  • Status: Expired due to Fees
First Claim
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1. A model system, wherein the model predicts, without dosing, the post-dose response of an individual where the response is dependent on the individual'"'"'s metabolic phenotype, the model system comprising:

  • a) pre-dose data of a plurality of subjects or samples thereof before dosing with a dosing substance;

    b) post-dose data of the plurality of subjects or samples thereof after dosing with the dosing substance; and

    c) a processor that identifies and correlates inter-subject variation in the pre-dose data with inter-subject variation in the post-dose data using a pattern recognition (PR) technique, wherein the inter-subject variation in the post-dose data corresponds to different responses of the subjects to the dosed substance, thereby producing a pre-to-post-dose predictive model,wherein the processor applies the pre-to-post-dose predictive model to the individual'"'"'s pre-dose data and classifies the individual'"'"'s post-dose response, without dosing of the individual;

    wherein the pre- and/or post-dose data comprise chemical composition data and/or physical parameter data of samples and/or subjects;

    wherein the pre-to-post-dose predictive model consists of one or more mathematical equations defining the relationship between pre-dose and post-dose data.

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