Ocular implant systems

• US 8,579,846 B2
• Filed: 11/21/2011
• Issued: 11/12/2013
• Est. Priority Date: 04/07/2001
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Tu, Hosheng, Smedley, Gregory T., Haffner, David, Niksch, Barbara A.
• Primary Examiner(s): DEAK, LESLIE R
• Application Number:
  US13/301,648
• Publication Number:
  US 20120071809A1
• Time in Patent Office: 722 Days
• Field of Search: 604/8, 604/9, 604/264, 623/4.1, 623/6.12, 606/107, 606/108
• US Class Current: 604/8
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 27/00 Drainage appliance for wounds or the like , i.e. wound drains, implanted drains negative pressure wound therapy devices A61M1/90; implements for holding wound open A61B17/02 ; middle ear drainage A61F11/202

Abstract

Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.

Claims

1. An ocular implant system for draining aqueous humor to a uveoscleral outflow path of an eye, comprising:

an ocular implant, the ocular implant comprising an elongated body, the elongated body including;

an inlet port arranged on a proximal end segment of the ocular implant to communicate with an anterior chamber of an eye;

an inner lumen communicating with the inlet port; and

at least one outlet port in communication with the inner lumen; and

an applicator preloaded with the ocular implant, the applicator including;

a handpiece having a proximal end and a distal end;

an elongated member coupled to the distal end of the handpiece, the elongated member being sized to pass through an incision in the eye and into the anterior chamber of the eye and to facilitate ab interno insertion and advancement of the ocular implant into an anterior chamber angle and then to an implantation location in uveal tissue of the eye,

wherein the elongated member has a sufficient length so as to extend from the incision into the anterior chamber to the implantation location in uveal tissue,

wherein the elongated member comprises a curved distal end portion that engages the ocular implant in a coaxial manner; and

a deployment mechanism configured to act upon the ocular implant, the deployment mechanism and the elongated member being movable relative to each other so as to deploy the ocular implant from the elongated member and into the implantation location in uveal tissue.

2. The system of claim 1, wherein the incision is a self-sealing incision.

3. The system of claim 2, wherein the self-sealing incision is a corneal incision.

4. The system of claim 1, wherein the proximal end segment of the ocular implant further comprises a flange configured to abut against ocular tissue when implanted, the flange being sized and shaped to reside in the anterior chamber angle of the eye.

5. The system of claim 4, wherein the inlet port is disposed on a proximal side of the flange.

6. The system of claim 4, wherein a portion of an intermediate segment of the ocular implant which lies next to the flange has a smaller external dimension than an external dimension of the flange.

7. The system of claim 1, wherein the applicator is sufficiently curved so as to extend over a portion of an iris of the eye and into the anterior chamber angle of the eye to access the implantation location with the elongated member extending through the incision into the anterior chamber.

8. The system of claim 1, wherein the at least one outlet port is disposed on a distal end segment of the ocular implant.

9. The system of claim 1, wherein the ocular implant comprises one or more retention features selected from the group consisting of stubs, ribs, pillars, textured surfaces, threads, flanges, and barbs.

10. The system of claim 1, wherein the elongated member of the applicator comprises a wire.

11. The system of claim 1, wherein the handpiece of the applicator comprises a syringe portion.

12. The system of claim 1, wherein the applicator further comprises an actuator that is configured to actuate the deployment mechanism.

13. The system of claim 1, wherein the curved distal end portion of the elongated member has a deflection range.

14. The system of claim 1, wherein the ocular implant is of a sufficient length so that at least a portion of the ocular implant contacts a choroid of the eye when the ocular implant is implanted in the eye.

15. The system of claim 1, wherein the ocular implant has sufficient length so as to contact ciliary tissue of the eye when implanted with the proximal end segment of the ocular implant exposed to the anterior chamber.

16. A system for implanting an ocular implant to drain aqueous humor from an anterior chamber of an eye to a uveoscleral outflow route of the eye, the system comprising:

an ocular implant, the ocular implant comprising a tubular body, the tubular body including;

an inlet port arranged on a proximal end segment of the ocular implant to communicate with an anterior chamber of an eye;

an inner lumen communicating with the inlet port; and

at least one outlet port in communication with the inner lumen; and

an applicator preloaded with the ocular implant, the applicator comprising;

a handpiece; and

an elongated member extending from the handpiece, the elongated member being configured to be placed into the anterior chamber of the eye and to facilitate ab interno insertion and advancement of the ocular implant to an implantation site in uveal tissue of the eye such that, when implanted, the ocular implant resides entirely within the confines of a cornea and a sclera of the eye, the elongated member further comprising a curved distal end portion configured to deliver the ocular implant to the implantation site, wherein the ocular implant and at least the curved distal end portion of the elongated member are positioned about a common axis before implantation.

17. The system of claim 16, wherein the ocular implant and elongated member have a combined cross-sectional size to fit through a self-sealing incision in the cornea or a corneal limbus of the eye when accessing the anterior chamber.

18. The system of claim 16, wherein the elongated member of the applicator comprises a wire.

19. The system of claim 16, wherein the ocular implant is of a sufficient length so that at least a portion of the ocular implant contacts a choroid of the eye when the ocular implant is implanted in the eye.

20. The system of claim 16, wherein the ocular implant is of a sufficient length so that at least a portion of the ocular implant contacts ciliary tissue of the eye when the ocular implant is implanted in the eye.

21. The system of claim 16, wherein the at least one outlet port is disposed on a distal end of the ocular implant.

22. The system of claim 16, wherein the curved distal end portion is sufficiently curved so as to extend over a portion of an iris of the eye and into an anterior chamber angle of the eye to access the implantation site with the elongated member extending through an opening into the anterior chamber.

23. The system of claim 16, wherein the curved distal end portion of the elongated member has a deflection range.

24. The system of claim 16, wherein the ocular implant includes one or more retention features selected from the group consisting of stubs, ribs, pillars, textured surfaces, threads, flanges, and barbs.

25. A system for implanting an ocular implant to drain aqueous humor from an anterior chamber of an eye to a uveoscleral outflow route of the eye, the system comprising:

an ocular implant including an inlet port, an outlet port, and a lumen extending between and communicating with the inlet port and the outlet port; and

a delivery device configured to advance the ocular implant from within the anterior chamber using an ab interno procedure, the delivery device advancing the ocular implant with the outlet port leading the inlet port and having a curved configuration at a distal end portion while advancing the ocular implant.

26. The system of claim 25, wherein the ocular implant and the delivery device have a combined cross-sectional size to fit through a self-sealing incision in a cornea or a corneal limbus of the eye when accessing the anterior chamber.

27. The system of claim 25, wherein the delivery device comprises a wire.

28. The system of claim 25, wherein the ocular implant is of a sufficient length so that at least a portion of the ocular implant contacts a choroid of the eye when the ocular implant is implanted in the eye.

29. The system of claim 25, wherein the ocular implant is of a sufficient length so that at least a portion of the ocular implant contacts ciliary tissue of the eye when the ocular implant is implanted in the eye.

30. The system of claim 25, wherein the distal end portion is sufficiently curved so as to extend over a portion of an iris of the eye and into an anterior chamber angle of the eye to access an implantation site with the elongated member extending through an opening into the anterior chamber.

31. The system of claim 25, wherein the distal end portion of the delivery device has a deflection range.