Active drainage systems with pressure-driven valves and electronically-driven pump

• US 8,579,848 B2
• Filed: 12/09/2011
• Issued: 11/12/2013
• Est. Priority Date: 12/09/2011
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Field, Leslie, Jenkins, Daniel, Rickard, Matthew
• Primary Examiner(s): HAND, MELANIE JO
• Application Number:
  US13/315,329
• Publication Number:
  US 20130150774A1
• Time in Patent Office: 704 Days
• Field of Search: 604 8- 10, 606 4- 6
• US Class Current: 604/9
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 1/74 Suction control underwater drainage A61M1/61
• CPC Class Codes: A61M 1/742 by changing the size of a vent A61M1/7411 takes precedence
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2210/0612 Eyes

Abstract

An IOP control system for implantation in an eye of a patient is disclosed. The IOP control system includes a drainage tube configured to convey aqueous humor from an anterior chamber of an eye and includes a pressure-driven valve system in fluid communication with the drainage tube and configured to control flow rates of the aqueous humor. The valve system includes a plurality of pressure-driven valves arranged to operate in cooperation with each other. The IOP control system may include an electronic pump system to further regulate flow.

Claims

1. An IOP control system for implantation in an eye of a patient, comprising:

a drainage tube configured to convey aqueous humor from an anterior chamber of the eye;

a pressure-driven valve system in fluid communication with the drainage tube, the valve system actuatable in response to pressure differentials acting on the pressure-driven valves and configured to control flow rates of the aqueous humor, the pressure-driven valve system comprising a first pressure-driven valve and a second pressure-driven valve arranged in series to operate independently of each other;

wherein the pressure-driven valves control flow rates of the aqueous humor along the drainage tube by shifting in response to pressure differentials between the anterior chamber of the eye, the drainage site, and the atmospheric pressure; and

further wherein the pressure-driven valves each include an S-shaped flow control member; and

an electrically-driven pump system in fluid communication with the drainage tube and the pressure-driven valve system, the electrically-driven pump system being arranged to selectively control aqueous humor flow rates through the drainage tube and influence the pressure differentials affecting the valve system.

2. The system of claim 1, wherein the electrically driven pump system is activated to pump aqueous humor from the anterior chamber when the electrically-driven pump system is in the vicinity of an external power source;

and the electrically driven pump system is deactivated when the electrically-driven pump system is not in the vicinity of an external power source.

3. The system of claim 1, wherein the pressure-driven valves each include a biasing member connected to the flow control member, the biasing member having an expanded condition and a contracted condition in response to pressure differentials moving the flow control member in a first direction and a second direction opposite the first direction.

4. The system of claim 1, further comprising a processor coupled to the electrically-driven pump system, a pressure sensor system coupled to the processor, and a power source, wherein the processor is configured to control the pump to adjust the rate of aqueous flow through the drainage tube based on sensed pressures.

5. The system of claim 4, wherein the electrically-driven pump system further comprises a memory coupled to the processor, wherein the processor writes values corresponding to sensed pressures to the memory.

6. The system of claim 4, further comprising a data transmission module coupled to the processor.

7. The system of claim 4, wherein the pressure sensor system comprises:

a first pressure sensor located in fluid communication with the anterior chamber of an eye; and

a second pressure sensor located at the drainage site;

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates a pressure differential between the anterior chamber and the drainage site.

8. The system of claim 4, wherein the pressure sensor system comprises:

a first pressure sensor configured for positioning in fluid communication with the anterior chamber of an eye; and

a second pressure sensor located remotely from the first pressure sensor such that the second pressure sensor measures atmospheric pressure,

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates IOP.

9. The system of claim 8, wherein the second sensor is configured to be disposed in the subconjunctival space of the eye.

10. The system of claim 4, wherein the pressure sensor system comprises:

a first pressure sensor configured for positioning in fluid communication with a drainage site; and

a second pressure sensor located remotely from the first pressure sensor such that the second pressure sensor measures atmospheric pressure,

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates the gauge drainage site pressure.

11. The system of claim 10, wherein the second sensor is configured to be disposed in the subconjunctival space of the eye.

12. An IOP control system for implantation in an eye of a patient, comprising:

a drainage tube configured to convey aqueous humor from an anterior chamber of the eye;

a pressure-driven valve system in fluid communication with the drainage tube, the valve system actuatable in response to pressure differentials acting on the pressure-driven valves and configured to control flow rates of the aqueous humor;

an electrically-driven pump system in fluid communication with the drainage tube and the pressure-driven valve system, the electrically-driven pump system being arranged to selectively control aqueous humor flow rates through the drainage tube and influence the pressure differentials affecting the valve system;

a processor coupled to the electrically-driven pump system;

a pressure sensor system coupled to the processor, the pressure sensor system comprising a first pressure sensor located in fluid communication with the anterior chamber of an eye and a second pressure sensor located at a drainage site;

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates a pressure differential between the anterior chamber and the drainage site; and

a power source;

wherein the processor is configured to control the pump to adjust the rate of aqueous flow through the drainage tube based on sensed pressures.

13. The system of claim 12, wherein the electrically-driven pump system further comprises a memory coupled to the processor, wherein the processor writes values corresponding to sensed pressures to the memory.

14. The system of claim 12, further comprising a data transmission module coupled to the processor.

15. The system of claim 12, wherein the power source is external to the eye and the electrically driven pump system is activated to pump aqueous humor from the anterior chamber when the pump is in the vicinity of the power source;

and the electrically driven pump system is deactivated when the pump is not in the vicinity of the power source.

16. An IOP control system for implantation in an eye of a patient, comprising:

a drainage tube configured to convey aqueous humor from an anterior chamber of the eye;

a pressure-driven valve system in fluid communication with the drainage tube, the valve system actuatable in response to pressure differentials acting on the pressure-driven valves and configured to control flow rates of the aqueous humor;

an electrically-driven pump system in fluid communication with the drainage tube and the pressure-driven valve system, the electrically-driven pump system being arranged to selectively control aqueous humor flow rates through the drainage tube and influence the pressure differentials affecting the valve system;

a processor coupled to the electrically-driven pump system;

a pressure sensor system coupled to the processor, the pressure sensor system comprising a first pressure sensor configured for positioning in fluid communication with the anterior chamber of an eye and a second pressure sensor located remotely from the first pressure sensor such that the second pressure sensor measures atmospheric pressure;

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates IOP; and

a power source;

wherein the processor is configured to control the pump to adjust the rate of aqueous flow through the drainage tube based on sensed pressures.

17. The system of claim 16, wherein the second sensor is configured to be disposed in the subconjunctival space of the eye.

18. The system of claim 16, wherein the electrically-driven pump system further comprises a memory coupled to the processor, wherein the processor writes values corresponding to sensed pressures to the memory.

19. The system of claim 16, further comprising a data transmission module coupled to the processor.

20. The system of claim 16, wherein the power source is external to the eye and the electrically driven pump system is activated to pump aqueous humor from the anterior chamber when the pump is in the vicinity of the power source;

and the electrically driven pump system is deactivated when the pump is not in the vicinity of the power source.

21. An IOP control system for implantation in an eye of a patient, comprising:

a drainage tube configured to convey aqueous humor from an anterior chamber of the eye;

a pressure-driven valve system in fluid communication with the drainage tube, the valve system actuatable in response to pressure differentials acting on the pressure-driven valves and configured to control flow rates of the aqueous humor;

an electrically-driven pump system in fluid communication with the drainage tube and the pressure-driven valve system, the electrically-driven pump system being arranged to selectively control aqueous humor flow rates through the drainage tube and influence the pressure differentials affecting the valve system;

a processor coupled to the electrically-driven pump system;

a pressure sensor system coupled to the processor, the pressure sensor system comprising a first pressure sensor configured for positioning in fluid communication with a drainage site and a second pressure sensor located remotely from the first pressure sensor such that the second pressure sensor measures atmospheric pressure;

wherein a difference between the readings from the first pressure sensor and the second pressure sensor approximates the gauge drainage site pressure; and

a power source;

wherein the processor is configured to control the pump to adjust the rate of aqueous flow through the drainage tube based on sensed pressures.

22. The system of claim 21, wherein the second sensor is configured to be disposed in the subconjunctival space of the eye.

23. The system of claim 21, wherein the electrically-driven pump system further comprises a memory coupled to the processor, wherein the processor writes values corresponding to sensed pressures to the memory.

24. The system of claim 21, further comprising a data transmission module coupled to the processor.

25. The system of claim 21, wherein the power source is external to the eye and the electrically driven pump system is activated to pump aqueous humor from the anterior chamber when the pump is in the vicinity of the power source;

and the electrically driven pump system is deactivated when the pump is not in the vicinity of the power source.