Tissue repair devices of rapid therapeutic absorbency

• US 8,579,990 B2
• Filed: 03/30/2011
• Issued: 11/12/2013
• Est. Priority Date: 03/30/2011
• Status: Active Grant

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Priewe, Joerg
• Primary Examiner(s): TYSON, MELANIE RUANO
• Application Number:
  US13/075,531
• Publication Number:
  US 20120253472A1
• Time in Patent Office: 958 Days
• Field of Search: 606/151, 623/1.13, 623/1.39, 623/1.46, 623/23.72, 600/37
• US Class Current: 623/23.72
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

Novel implantable tissue repair medical devices are disclosed. The devices have a central fabric member having anti-adhesion films on both opposed sides. The films have pores, and are arranged such that the pores on the opposed films are offset. The devices are useful in hernia repair procedures.

Claims

1. A tissue implant medical device, comprising:

a tissue repair member having a plurality of member pores, the repair member having opposed first and second sides;

a first polymer film, having first film pores, the first polymer film mounted to the first side of the member; and

,

a second polymer film, having second film pores, the second polymer film mounted to the second side of the repair member, wherein the first film pores are not in alignment with the second film pores.

2. The medical device of claim 1, further comprising an active agent.

3. The medical device of claim 2, wherein the active agent is selected from the group consisting of, antibiotics, chemotherapeutics, cytostatics, metastasis inhibitors, antidiabetics, antimycotics, antimicrobials, antibacterials, vitamins, gynaecological agents, urological agents, anti-allergic agents, sexual hormones, sexual hormone inhibitors, local anesthetics, haemostyptics, hormones, peptide hormones, vitamins, antidepressants, anti-histamines, naked DNA, plasmid DNA, cationic DNA complexes, RNA, cell constituents, vaccines, cells occurring naturally in the body, genetically modified cells and combinations thereof.

4. The medical device of claim 3, wherein the active agent is an antimicrobial selected from the group consisting of octenidine, PHMB, triclosan, copper, silver, nanosilver, gold, selenium, gallium, taurolidine, cyclotaurolidine, N-chlorotaurine, alcohol, LAE, MAPD, OAPD, and mixtures thereof.

5. The medical device of claim 4, wherein the antimicrobial is triclosan.

6. The medical device of claim 4, wherein the antimicrobial is octenidine.

7. The medical device of claim 4, wherein the antimicrobial is PHMB.

8. The medical device of claim 1, wherein the tissue repair member is a fabric.

9. The medical device of claim 8, wherein the tissue repair fabric is selected from the group consisting of meshes, woven fabrics, nonwoven fabrics and tapes.

10. The medical device of claim 9, wherein the tissue repair fabric comprises a mesh.

11. The medical device of claim 1, wherein the tissue repair member comprises a biocompatible nonabsorbable polymer selected from the group consisting of polyalkenes, polypropylene, polyethylene, fluorinated polyolefins, polytetrafluoroethylene, polyvinylidenefluoride, polyamides, polyurethanes, polyisoprenes, polystyrenes, polysilicones, polycarbonates, polyaryletherketones, polymethacrylates, polyacrylates, aromatic polyesters, polyimides, cellulose, copolymers of polymerisable substances thereof.

12. The medical device of claim 1, wherein the tissue repair member comprises a bioabsorbable polymer selected from the group consisting of polyhydroxy acids, polylactides, polyglycolides, polyhydroxybutyrates, polyhy droxyvaleriates, polycaprolactones, polydiaxanones, synthetic and natural oligo- and polyaminoacids, polyphosphazenes, polyanhydrides, polyorthoesters, polyoxaester, polyphosphates, polyphosphonates, polyalcohols, polysaccharides, polyethers, resorbable glasses, copolymers of polymerizable substances thereof.

13. The medical device of claim 1 wherein the first and second films comprise a biocompatible nonabsorbable polymer selected from the group consisting of polyolefins, polyester, Nylon, Teflon, polyvinidenefluoride, and cellulose.

14. The medical device of claim 1 wherein the first and second films comprise a biocompatible bioabsorbable polymer selected from the group consisting of polyhydroxy acids, polylactides, polyglycolides, polyhydroxy butyrates, polyhydroxy valeriates, polycaprolactones, polydioxanones, synthetic and natural oligo- and polyamino acids, polyphosphazenes, polyanhydrides, polyorthoesters, polyphosphates, polyphosphonates, polyalcohols, polysaccharides, polyethers, polyamides, aliphatic polyesters, aromatic polyesters, copolymers of polymerizable substances thereof, and resorbable glasses.

15. The medical device of claim 1, wherein the film pores of the first and second polymer films have a size ranging from about 0.1 mm to about 5 mm.

16. The medical device of claim 1, wherein the films have a thickness of about 5 μ

m to about 50 μ

m.

17. The medical device of claim 1, wherein the tissue repair member comprises monofilament fibers.

18. The medical device of claim 1, wherein the tissue repair member comprises multifilament fibers.

19. The medical device of claim 1, additionally comprising a polymeric coating.

20. The medical device of claim 1, wherein the pores have a substantially circular cross-section.

21. The medical device of claim 1, wherein the film pores of the first and second polymer films comprise slits.

22. A method of repairing a tissue defect, comprising the steps of:

inserting a tissue repair implant device adjacent to a tissue defect, wherein the device comprises;

a tissue repair member having a plurality of member pores, the repair member having opposed first and second sides;

a first polymer film, having first film pores, the first polymer film mounted to the first side of the member; and

,

a second polymer film, having second film pores, the second polymer film mounted to the second side of the repair member,

wherein the first film pores are not in alignment with the second film pores; and

,

securing the repair device to the tissue defect.

23. The method of claim 22, additionally comprising the step of immersing the device in a solution containing an active agent prior to inserting the tissue repair device.

24. The combination, comprising:

a) A tissue implant medical device, comprising;

a tissue repair member having a plurality of member pores, the repair member having opposed first and second sides;

a first polymer film, having first film pores, the first polymer film mounted to the first side of the member; and

,

a second polymer film, having second film pores, the second polymer film mounted to the second side of the repair member,

wherein the first film pores are not in alignment with the second film pores; and

,

b) An active agent.

25. The combination of claim 24, wherein the active agent is in a solution.