PS-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
First Claim
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1. A method of cancer immunotherapy comprising:
- administering a cytokine-expressing cellular immunotherapy comprising cells modified to express GM-CSF and a single chain antibody that specifically binds to human Programmed Death 1 (anti-PD-1) to a subject with cancer,wherein the modified cells are rendered proliferation-incompetent by irradiation, andwherein administration of the cells modified to express GM-CSF and the single chain antibody results in enhanced therapeutic efficacy relative to administration of an anti-PD-1 antibody alone or cells modified to express GM-CSF alone.
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Abstract
The present invention relates to a method of enhancing the anti-tumor response in a mammal. More particularly, the invention is concerned with combinations comprising a cytokine-secreting cell and an anti-PD-1 antibody, and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer.
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Citations
19 Claims
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1. A method of cancer immunotherapy comprising:
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administering a cytokine-expressing cellular immunotherapy comprising cells modified to express GM-CSF and a single chain antibody that specifically binds to human Programmed Death 1 (anti-PD-1) to a subject with cancer, wherein the modified cells are rendered proliferation-incompetent by irradiation, and wherein administration of the cells modified to express GM-CSF and the single chain antibody results in enhanced therapeutic efficacy relative to administration of an anti-PD-1 antibody alone or cells modified to express GM-CSF alone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification