Tissue matrix system
First Claim
1. A matrix composition for supporting repair of a tissue comprising polyester polymers entangled with hyaluronic acid polymers, wherein the polyester polymers are selected from the group consisting of polylactic acid, polyglycolic acid, and a co-polymer consisting of polylactic acid and polyglycolic acid, said composition being formed by the steps of:
- (i) dissolving the polyester polymers in an organic solvent;
(ii) blending the polyester polymers with hyaluronic acid polymers contained in an aqueous medium to form an emulsified mixture;
(iii) freezing the emulsified mixture of the two polymers, and (iv) successively removing the organic solvent and water from the frozen mixture;
wherein said composition is characterized by (a) retention of pore structure when hydrated and (b) the ability to support the growth of cells in vivo or ex vivo.
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Abstract
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.
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Citations
20 Claims
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1. A matrix composition for supporting repair of a tissue comprising polyester polymers entangled with hyaluronic acid polymers, wherein the polyester polymers are selected from the group consisting of polylactic acid, polyglycolic acid, and a co-polymer consisting of polylactic acid and polyglycolic acid, said composition being formed by the steps of:
- (i) dissolving the polyester polymers in an organic solvent;
(ii) blending the polyester polymers with hyaluronic acid polymers contained in an aqueous medium to form an emulsified mixture;
(iii) freezing the emulsified mixture of the two polymers, and (iv) successively removing the organic solvent and water from the frozen mixture;
wherein said composition is characterized by (a) retention of pore structure when hydrated and (b) the ability to support the growth of cells in vivo or ex vivo. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- (i) dissolving the polyester polymers in an organic solvent;
Specification