Method, composition, and system to control pH in pulmonary tissue of a subject
First Claim
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1. A system comprising:
- a pharmaceutical composition including at least one agent configured as two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of pulmonary tissue of a subject, wherein the at least one agent is configured to achieve a selected pH range in the two or more levels of pulmonary tissue of the subject; and
an aerosol generator configured to generate an aerosol dose of the pharmaceutical composition, the aerosol generator being operably coupled to at least one of a heating, ventilation, or air conditioning system to allow delivery of at least a portion of the aerosol dose of the pharmaceutical composition therethrough.
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Abstract
Methods, pharmaceutical compositions, and systems are provided which include a method for treating a pulmonary viral infectious disease in a subject. The method includes administering a pharmaceutical composition including at least one agent to a pulmonary tissue of the subject, wherein the pharmaceutical composition is administered as two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of pulmonary tissue of the subject, wherein the at least one agent is configured to achieve a selected pH range in the two or more levels of pulmonary tissue of the subject.
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Citations
51 Claims
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1. A system comprising:
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a pharmaceutical composition including at least one agent configured as two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of pulmonary tissue of a subject, wherein the at least one agent is configured to achieve a selected pH range in the two or more levels of pulmonary tissue of the subject; and an aerosol generator configured to generate an aerosol dose of the pharmaceutical composition, the aerosol generator being operably coupled to at least one of a heating, ventilation, or air conditioning system to allow delivery of at least a portion of the aerosol dose of the pharmaceutical composition therethrough. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51)
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50. A system comprising:
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a pharmaceutical composition including at least one agent configured as two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of pulmonary tissue of a subject, wherein the at least one agent is configured to achieve a selected pH range in the two or more levels of pulmonary tissue of the subject; and an aerosol generator configured deliver the pharmaceutical composition to the subject or a group of subjects in a man-made enclosed area, the aerosol generator being incorporated into at least one of a computer screen, a keyboard, a telephone receiver, or a seat back.
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Specification