Fluid extraction or filtration device, associated materials and methods
First Claim
1. A method employing a device comprising an array of microneedles for contacting fluid in a body of a patient and a dry absorbent gel matrix in fluid communication with said array of microneedles, wherein a first region of the array of microneedles is arranged for contacting the fluid and a second region of the array of microneedles is arranged for contacting the dry absorbent get matrix, separate from the first region, the method comprisingcontacting said fluid with said first region of the array of microneedles so as to establish an osmotic gradient between the fluid and the dry absorbent gel matrix such that said fluid flows from said body to said dry absorbent gel matrix via said microneedles.
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Accused Products
Abstract
A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.
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Citations
23 Claims
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1. A method employing a device comprising an array of microneedles for contacting fluid in a body of a patient and a dry absorbent gel matrix in fluid communication with said array of microneedles, wherein a first region of the array of microneedles is arranged for contacting the fluid and a second region of the array of microneedles is arranged for contacting the dry absorbent get matrix, separate from the first region, the method comprising
contacting said fluid with said first region of the array of microneedles so as to establish an osmotic gradient between the fluid and the dry absorbent gel matrix such that said fluid flows from said body to said dry absorbent gel matrix via said microneedles.
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9. A fluid extraction or filtration device adapted for removing fluid from a body of a patient, comprising:
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an array of microneedles for contacting fluid in said body, comprising a first region configured for contacting said fluid, and a separate second region, and an absorbent gel matrix in fluid communication with said array of microneedles, in contact said separate second region of said array of microneedles so as to establish an osmotic gradient between the fluid and the absorbent gel matrix; wherein said absorbent gel matrix is dry prior to contacting the fluid. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification