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Long lasting drug formulations

  • US 8,586,024 B2
  • Filed: 06/30/2011
  • Issued: 11/19/2013
  • Est. Priority Date: 09/14/2006
  • Status: Expired due to Fees
First Claim
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1. A long-lasting therapeutic formulation for implanting into an immunocompetent human subject comprising:

  • a genetically modified dermal micro-organ, wherein said dermal micro-organ consists essentially of dermal tissue and lacks a complete epidermal layer, wherein said dermal micro-organ is transduced in vitro with a helper-dependent adenoviral vector comprising the nucleic acid sequence set forth in SEQ ID NO;

    2, wherein said nucleic acid sequence encodes for interferon and is operably linked to one or more regulatory sequences, wherein said one or more regulatory sequences comprise a CAG promoter, wherein following said transduction the genetically modified dermal micro-organ is maintained ex vivo prior to implantation in order to reduce the immunogenicity of said formulation and wherein implantation of said long-lasting formulation in said immunocompetent human subject provides a beneficial effect selected from the group consisting of;

    a. an increase in expression levels of said interferon in the serum compared with pre-implantation basal levels, said increase persisting for greater than one month; and

    b. an alleviation of a symptom of a disease or disorder in said subject, wherein said alleviation persists for greater than one month.

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