Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages
First Claim
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1. A polymer having the formula:
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A-X-A-Bn wherein;
A are poly(hydroxyacid) or poly(hydroxy-alkanoate) blocks;
B are blocks of a biologically compatible polymer;
X is a linking moiety; and
n is an integer between 2 and 700;
wherein the linking moiety is derived from at least one of or any combination of oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, brassylic acid, dodecane-1,12-dicarboxylic acid, tridecane-1,13-dicarboxylic acid, thapsic acid, fumaric acid, maleic acid, and 1,3-acetonedicarboxylic acid;
wherein the biologically compatible polymer is poly(L-lysine)-graft-co-poly(ethylene glycol; and
wherein the poly(hydroxyacid) or poly(hydroxy-alkanoate) is one of poly(lactide-co-glycolide);
poly(L-lactide);
poly(D-lactide);
poly(D,L-lactide);
poly(L-lactide-co-glycolide);
poly(D,L-lactide-co-glycolide);
poly(L-lactide-co-caprolactone);
poly(D,L-lactide-co-caprolactone);
poly(L-lactide-co-D,L-lactide);
poly(L-lactide-co-trimethylene carbonate);
poly(D,L-lactide-co-trimethylene carbonate);
poly(L-lactic acid);
poly(D-lactic acid);
poly(D,L-lactic acid);
or a combination thereof.
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Abstract
Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings include block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.
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Citations
20 Claims
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1. A polymer having the formula:
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A-X-A-Bnwherein; A are poly(hydroxyacid) or poly(hydroxy-alkanoate) blocks; B are blocks of a biologically compatible polymer; X is a linking moiety; and n is an integer between 2 and 700; wherein the linking moiety is derived from at least one of or any combination of oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, brassylic acid, dodecane-1,12-dicarboxylic acid, tridecane-1,13-dicarboxylic acid, thapsic acid, fumaric acid, maleic acid, and 1,3-acetonedicarboxylic acid; wherein the biologically compatible polymer is poly(L-lysine)-graft-co-poly(ethylene glycol; and wherein the poly(hydroxyacid) or poly(hydroxy-alkanoate) is one of poly(lactide-co-glycolide);
poly(L-lactide);
poly(D-lactide);
poly(D,L-lactide);
poly(L-lactide-co-glycolide);
poly(D,L-lactide-co-glycolide);
poly(L-lactide-co-caprolactone);
poly(D,L-lactide-co-caprolactone);
poly(L-lactide-co-D,L-lactide);
poly(L-lactide-co-trimethylene carbonate);
poly(D,L-lactide-co-trimethylene carbonate);
poly(L-lactic acid);
poly(D-lactic acid);
poly(D,L-lactic acid);
or a combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 13, 14, 15, 16, 17, 18, 19, 20)
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7. A method of making a polymer comprising:
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reacting at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) with at least one chain extending compound that is derived from at least one of or any combination of oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, brassylic acid, dodecand-1,12-dicarboxylic acid, tridacane-1,13-dicarboxlic acid, thapsic acid, fumaric acid, maleic acid, and 1,3-acetonedicarboxylic acid, such that an A-X-A block polymer is formed; and reacting the A-X-A block copolymer with a biologically compatible polymer such that a final block copolymer is formed having the formula;
A-X-A-Bnwherein A are poly(hydroxyacid) or poly(hydroxy-alkanoate) blocks; B are blocks of the biologically compatible polymer; X is a linking moiety that corresponds to the chain extending compound; and n is an integer between 2 and 700; wherein the biologically compatible polymer is poly(L-lysine)-graft-co-poly(ethylene glycol); and wherein the poly(hydroxyacid) or poly(hydroxy-alkanoate) is one of poly(lactide-co-glycolide);
poly(L-lactide);
poly(D-lactide);
poly(D,L-lactide);
poly(L-lactide-co-glycolide);
poly(D,L-lactide-co-glycolide);
poly(L-lactide-co-caprolactone);
poly(D,L-lactide-co-caprolactone);
poly(L-lactide-co-D,L-lactide);
poly(L-lactide-co-trimethylene carbonate);
poly(D,L-lactide-co-trimethylene carbonate);
poly(L-lactic acid);
poly(D-lactic acid);
poly(D,L-lactic acid);
or any combination of these. - View Dependent Claims (8, 9, 10, 11, 12)
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Specification