Bioresorbable bone mineral substitute comprising water-soluble X-ray contrast agent

• US 8,586,101 B2
• Filed: 12/20/2002
• Issued: 11/19/2013
• Est. Priority Date: 12/20/2001
• Status: Active Grant

• Current Assignee: BONE Support NYA AB
• Original Assignee: Bone Support AB (BONESUPPORT HOLDING AB)
• Inventors: Lidgren, Lars
• Primary Examiner(s): Orwig, Kevin S
• Application Number:
  US10/499,023
• Publication Number:
  US 20050119746A1
• Time in Patent Office: 3,987 Days
• Field of Search: 424/9.4, 623/16.11
• US Class Current: 424/602
• CPC Class Codes: A61K 49/0433 containing an organic halogenated X-ray contrast-enhancing agent
• CPC Class Codes: A61K 49/0438 Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
• CPC Class Codes: A61L 2300/428 Vitamins, e.g. tocopherol, riboflavin
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

The invention refers to an artificial bone mineral substitute material which comprises at least one ceramic and at least one water soluble non-ionic X-ray contrast agent. The invention refers to a composition for producing the same, which further comprises an aqueous liquid, as well as the use of the composition as a X-ray contrast medium.

Claims

1. An artificial bone mineral substitute material prepared from powder and aqueous components, the artificial bone mineral substitute material being bioresorbable and comprising from 52.92 wt % to 59.6 wt % of calcium sulfate hemihydrate relative to the total weight of the powder components, from 36 wt % to 40 wt % of hydroxyapatite relative to the total weight of the powder components, a water soluble non-ionic X-ray contrast agent, an accelerator, which is calcium sulfate dihydrate, and an aqueous liquid, wherein said bone mineral substitute material does not include polymethylmethacrylate (PMMA).

2. The artificial bone mineral substitute material of claim 1, wherein the water soluble non-ionic X-ray contrast agent is chosen from iohexol, ioversol, iopamidol, iotrolane, iodixanol, metrizamide, iodecimol, loglucol, ioglucamide, ioglunide, iogulamide, iomeprol, iopentol, iopromide, iosarcol, iosimide, iotusal, ioxilane, iofrotal, and iodecol.

3. The artificial bone mineral substitute material of claim 1, wherein the water soluble non-ionic X-ray contrast agent is iohexol.

4. The artificial bone mineral substitute material of claim 1, which further comprises at least one osteogenic factor.

5. The artificial bone mineral substitute material of claim 1, which further comprises vitamin E.

6. The artificial bone mineral substitute material of claim 1, wherein said calcium sulfate hemihydrate is calcium sulfate α

-hemihydrate.

7. The artificial bone mineral substitute material of claim 1, wherein the calcium sulfate dihydrate is present in an amount from 0.1 wt % to 10 weight % relative to the total weight of the powder components.

8. The artificial bone mineral substitute material of claim 1, wherein the aqueous liquid is distilled water.

9. The artificial bone mineral substitute material of claim 1, wherein the powder components and the aqueous liquid are present in a liquid/powder ratio between 0.1 ml/g and 0.4 ml/g.

10. An artificial bone mineral substitute material prepared from powder and aqueous components, the artificial bone mineral substitute material being bioresorbable and comprising 59.6 wt % of calcium sulfate hemihydrate relative to the total weight of the powder components, 40 wt % of hydroxyapatite relative to the total weight of the powder components, iohexol, an accelerator, which is calcium sulfate dihydrate, and an aqueous liquid, wherein said bone mineral substitute material does not include polymethylmethacrylate (PMMA).