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System and method for determining the concentration of an analyte in a sample fluid

  • US 8,586,373 B2
  • Filed: 10/24/2012
  • Issued: 11/19/2013
  • Est. Priority Date: 06/20/2003
  • Status: Expired due to Term
First Claim
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1. A method for determining a concentration of an analyte of interest in a biological sample, comprising:

  • a) applying a first signal having a first AC component to the sample;

    b) measuring a first response to the first signal;

    c) applying a second signal having a second AC component to the sample;

    d) measuring a second response to the second signal;

    e) applying a third signal having a third AC component to the sample;

    f) measuring a third response to the third signal;

    g) applying a fourth DC signal to the sample;

    h) measuring a fourth response to the fourth DC signal; and

    e) determining the analyte concentration of the sample using at least the first, second and third responses to correct the fourth response for the effects of at least one interferent within the sample, wherein the determination has a Total Test Time of within about 2.0 seconds or less, and wherein the first, second third, and fourth signals are applied to the sample during separate time periods;

    wherein the first signal is applied for no more than about 100 ms before the first response is measured;

    wherein the second signal is applied for no more than about 100 ms before the second response is measured;

    wherein the third signal is applied for no more than about 100 ms before the third response is measured; and

    wherein the fourth signal is applied for no more than about 200 ms before the fourth response is measured.

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