System and method for radioactive emission measurement

• US 8,586,932 B2
• Filed: 05/09/2007
• Issued: 11/19/2013
• Est. Priority Date: 11/09/2004
• Status: Active Grant

• Current Assignee: Spectrum Dynamics Medical Ltd
• Original Assignee: Spectrum Dynamics LLC
• Inventors: Rousso, Benny, Ben-Haim, Shlomo, Nagler, Michael, Ziv, Omer, Ravhon, Ran, Dickman, Dalia, Zilberstein, Yoel, Dichterman, Eli, Ben-Haim, Simona, Vallabhajosula, Shankar, Berman, Daniel, Bronshtine, Zohar, Popper, Ziv, Weissberg, Nir, Roth, Nathaniel, Melman, Haim
• Primary Examiner(s): Bryant, Casey
• Application Number:
  US11/798,017
• Publication Number:
  US 20080042067A1
• Time in Patent Office: 2,386 Days
• Field of Search: 25036304-36309, 600/407, 600/408, 600/424, 600425-429, 600/431, 600/436, 600/448
• US Class Current: 250/363.04
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/1603 with a combination of at least two different types of detector see provisionally also G01T1/16
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/1648 Ancillary equipment for scintillation cameras, e.g. reference markers, devices for removing motion artifacts, calibration devices adapted for flow studies G01T1/1647

Abstract

A method of radioactive-emission-measurement. The method comprises providing a camera for the detection of single emissions, which defines proximal and distal ends. The camera is configured for enabling a reconstruction of a volumetric image having a line spread function of less than 7 mm Full Width Half Maximum (FWHM) when given a substantially line source of radioactive emission, with an activity of 5 mCi, within a region-of-interest volume, at a distance of at least 100 mm from said distal end, with air being substantially the only operating medium. The method further comprises detecting at least 1 of every 5000 photons, emitted from at least one radioactive-emission source, located within a certain region-of-interest volume, using the camera, and reconstructing a volumetric radioactive-emission image from the detected photons.

Claims

1. A method of radioactive-emission-measurement, comprising:

providing a SPECT camera for the detection of single emissions, which camera having a region of interest having a volume of at least 5×

5×

5 cm and a side closer to said region of interest;

arranging said camera so that said region of interest coincides with a human body;

imaging the region of interest from different orientations, using at least three detecting blocks each arranged to view said region of interest at a different orientation from others of said blocks, wherein said imaging comprises detecting at least 1 of every 5000 photons emitted from at least one radioactive-emission source located within said region-of-interest volume, through a collimator positioned in front of at least one pixel of each of the detecting blocks thereby blocking gamma and beta radiation and defining a viewing angle of at least 0.005 steradians; and

reconstructing a SPECT volumetric radioactive-emission image from said detected photons at a resolution of 7 mm Full Width Half Maximum (FWHM) or better, said resolution defined under conditions of irradiation by a substantially line source of radioactive emission, with an activity of 5 mCi, within said region-of-interest volume, at a distance of at least 100 mm from said side.

2. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 4000 photons emitted from the region-of-interest volume.

3. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 3000 photons emitted from the region-of-interest volume.

4. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 2000 photons emitted from the region-of-interest volume.

5. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 1000 photons emitted from the region-of-interest volume.

6. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 500 photons emitted from the region-of-interest volume.

7. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 200 photons emitted from the region-of-interest volume.

8. The method of claim 1, wherein said imaging comprises detecting at least 1 of every 100 photons emitted from the region-of-interest volume.

9. The method of claim 1, wherein said reconstructing comprises reconstructing at a resolution, which is better than 6 mm Full Width Half Maximum (FWHM).

10. The method of claim 1, wherein said reconstructing comprises reconstructing at a resolution, which is better than 5 mm Full Width Half Maximum (FWHM).

11. The method of claim 1, wherein said reconstructing comprises reconstructing of a volumetric image having a line spread function, which is better than 4 mm Full Width Half Maximum (FWHM).

12. The method of claim 1, wherein said reconstructing comprises reconstructing at a resolution, which is better than 3 mm Full Width Half Maximum (FWHM).

13. The method of claim 1, wherein said reconstructing comprises reconstructing at a resolution, which is better than 2 mm Full Width Half Maximum (FWHM).

14. The method of claim 1, wherein said reconstructing comprises reconstructing at a resolution which is better than 1 mm Full Width Half Maximum (FWHM).

15. The method of claim 1, wherein when the line source has an activity of 5 mCi, said detecting comprises acquiring 10 million photons emitted from the line source, in less than 60 seconds.

16. The method of claim 1, wherein when the line source has an activity of 5 mCi, said detecting comprises acquiring 10 million photons emitted from the line source, in less than 50 seconds.

17. The method of claim 1, wherein when the line source has an activity of 5 mCi, said detecting comprises acquiring 10 million photons emitted from the line source, in less than 40 seconds.

18. The method of claim 1, wherein when the line source has an activity of 5 mCi, said detecting comprises acquiring 10 million photons emitted from the line source, in less than 30 seconds.

19. The method of claim 1, wherein the volumetric radioactive-emission image is a three-dimensional image.

20. The method of claim 19, wherein given a substantially uniform radioactive-emission cylindrical source of 10 cm in diameter, as the region-of-interest volume, positioned substantially at a center of viewing of the camera, the reconstructed image has an intensity variation of no more than about 30%, so as to be substantially artifact free.

21. The method of claim 19, wherein given a substantially uniform radioactive-emission cylindrical source of 10 cm in diameter, as the region-of-interest volume, positioned substantially at a center of viewing of the camera, the reconstructed image has an intensity variation of no more than about 20%, so as to be substantially artifact free.

22. The method of claim 19, wherein given a substantially uniform radioactive-emission cylindrical source of 10 cm in diameter, as the region-of-interest volume, positioned substantially at a center of viewing of the camera, the reconstructed image has an intensity variation of no more than about 10%, so as to be substantially artifact free.

23. The method of claim 19, wherein given a substantially uniform radioactive-emission cylindrical source of 10 cm in diameter, as the region-of-interest volume, positioned substantially at a center of viewing of the camera, the reconstructed image has an intensity variation of no more than about 5%, so as to be substantially artifact free.

24. The method of claim 1, wherein:

wherein said at least one detecting unit has a freedom of motion in at least one direction with respect to another of said detecting units, wherein at each position and orientation of the detecting unit, the detecting unit defines a view;

and comprising;

determining a probability that a photon emitted at a voxel, centered at an x;

y;

z position, in a volume, relative to the camera for the detection of single emissions, will be detected by the detecting unit, at a given view;

providing a first algorithm for choosing a plurality of views, for the detecting unit;

moving the detecting unit to positions associated with the plurality of views and obtaining radioactive-emission-measurements at the positions; and

providing a second algorithm for reconstructing a volumetric radiation distribution, within the volume, from the radioactive-emission-measurements at the positions.

25. The method of claim 24, wherein said camera is tailored to a body structure, and optimized with respect to functional information gained about the body structure provided by said reconstructing, wherein the method further includes:

modeling the body-structure, based on its geometry;

modeling anatomical constraints, which limit accessibility to the body structure;

obtaining a collection of views of the modeled body-structure, within the modeled anatomical constraints;

providing a scoring function, by which any set of at least one view, from the collection of views, is scorable with a score that rates the functional information obtained from the modeled body structure, by the set;

forming sets of views from the collection of views and scoring them, with the scoring function; and

selecting one of the sets of views, from the collection of views, based on its score, as a predefined set of views.

26. The method of claim 25, wherein the scoring function is based on an information theoretic measure of uniformity.

27. The method of claim 25, wherein the modeling the body-structure includes modeling a radiation emission density distribution to form at least one region of interest.

28. The method of claim 27, wherein the scoring function is based on an information theoretic measure of reliability.

29. The method of claim 28, wherein:

the modeling the body-structure comprises providing a plurality of models of substantially identical volumes, but different regions of interest, the forming sets of views from the collection of views and scoring them, comprises forming substantially identical sets of views for all the models and scoring the sets with respect to each model, based on the information theoretic measure of reliability;

the selecting one of the sets of views, based on its score, comprises selecting based on the average score for the plurality of models.

30. The method of claim 27, wherein:

the modeling the body-structure comprises providing a pair of models of substantially identical volumes, but different regions of interest, wherein the difference between the regions of interest is defined by at least one delta;

the scoring function is based on an information theoretic measure of separability;

the forming the sets of views from the collection of views and scoring them, comprises forming substantially identical sets of views for the pair of models and scoring the sets with respect to the pair; and

the selecting one of the sets of views, based on its score, comprises selecting based on the score for the pair.

31. The method of claim 27, wherein:

the modeling the body-structure comprises providing a plurality of pairs of models of substantially identical volumes, but different regions of interest, wherein the difference between the regions of interest for each pair is defined by at least one delta;

the scoring function is based on an information theoretic measure of separability;

the forming the sets of views from the collection of views and scoring them, comprises forming substantially identical sets of views for the plurality of pairs of models and scoring the sets with respect to each of the pairs; and

the selecting one of the sets of views, based on its score, comprises selecting based on an average score for the plurality of pairs.

32. The method of claim 25, wherein:

the modeling the body-structure comprises providing at least one model of no radiation emission density distribution and at least two models of different radiation emission density distributions, so as to form different regions of interest for those two models; and

the providing the scoring function comprises providing a scoring function as a combination of uniformity, separability and reliability.

33. The method of claim 25, wherein the forming sets of views from the collection of views and scoring them, with the scoring function, includes using the Greedy construction.

34. The method of claim 25, wherein each view of the collection of views is determined for a given detecting unit, by at least one parameter selected from the group consisting of a location, an orientation, a pharmaceutical, a duration of measurement, and a time elapsed form the administration of the pharmaceutical.

35. The method of claim 25, wherein each view of the collection of views is determined at least by one detecting-unit parameter selected from the group consisting of a detector'"'"'s material, a detector'"'"'s thickness, a collimator'"'"'s collection angle, and a diameter of the detecting unit.

36. The method of claim 25, wherein the obtaining the collection of views comprises computing the group of probabilities which form each view, analytically.

37. The method of claim 25, wherein the obtaining the collection of views comprises obtaining the group of probabilities which form each view, by computer simulations, based on the model of the body structure and the view parameters.

38. The method of claim 25, wherein the obtaining the collection of views comprises obtaining the group of probabilities which form each view, by measurements of a substantially point source from different locations and orientations, by a detecting unit.

39. The method of claim 25, wherein the obtaining the collection of views comprises obtaining the group of probabilities which form each view, by measurements of a physical model of the body structure, embedded with an emission source, from different locations and orientations, by a detecting unit.

40. The method of claim 25, wherein the body structure is selected from the group consisting of a prostate, a heart, a brain, a breast, a uterus, an ovary, a liver, a kidney, a stomach, a colon, a small intestine, an oral cavity, a throat, a gland, a lymph node, the skin, another body organ, a limb, a bone, another part of the body, and a whole body.

41. The method of claim 25, wherein the body structure is selected from the group consisting of a human body structure and an animal body structure.

42. The method of claim 25, wherein the modeling the body-structure comprises modeling based on at least one factor selected from the group consisting of age, sex, weight and body type.

43. A method according to claim 1, wherein said camera is a radioactive-emission camera, for radioactive-emission imaging without coincidence, the camera being designed and constructed having high sensitivity selected from a group consisting of:

(a) sensitivity in terms of speed of data collection and spatial resolution, at least as good as a gold standard for PET imaging for at rest myocardial perfusion with N-13-ammonia (NH₃), at a dose of 740 MBq with attenuation correction;

(b) sensitivity sufficient for reconstructing an image under a Cobalt wire Nema test of a line source of 5 mCi cobalt with a line spread function of less than 7 mm Full Width Half Maximum (FWHM) through air at a distance of at least 100 mm;

(c) sensitivity sufficient for resolving through air at a distance of at least 100 mm under a Nema Bar Phantom test of gaps formed between 1 mm wide led bars positioned less than 7 mm apart from one another over a uniform cobalt disc;

(d) sensitivity operative for image acquisition of a full organ in less than 10 seconds at a spatial resolution, capable of identifying objects not greater than about 7 mm×

7 mm×

7 mm with a signal-to-noise ratio of at least 4 to 1 or better; and

/or

(e) sensitivity allowing acquisition of at least 1 out of every 5000 emitted photons while allowing a reconstructions of a 3D image with a resolution of not more than 5 mm and energy resolution of not more than 15%.

44. The method of claim 43, wherein said sensitivity of said camera is selected to be

at least 2 fold that of said gold standard for PET imaging.

45. A method according to claim 43, wherein said sensitivity allows acquisition of at least 1 out of every 5000 emitted photons while allowing a reconstruction of a 3D image with a resolution of 5 mm or better and energy resolution of 15% or better.

46. A method according to claim 1, comprising providing Teboroxime-Tc99m into said body and wherein said reconstructing comprises reconstructing a distribution of said Teboroxime-Tc99m in said region of interest.

47. A method according to claim 1, wherein said camera has a geometry which aligns said region of interest with said detectors and collimation thereof so that at least 1 in 5000 photons from said region of interest is absorbed by the detectors.

48. The method of claim 43, wherein said sensitivity of said camera is selected to be at least 5 fold that of said gold standard for PET imaging.

49. The method of claim 43, wherein said sensitivity of said camera is selected to be at least 10 fold that of said gold standard for PET imaging.

50. The method of claim 43, wherein said sensitivity of said camera is selected from a group consisting of:

sufficient for reconstructing an image under a Cobalt wire Nema test of said line source of 5 mCi cobalt with a line spread function of less than 6 mm Full Width Half Maximum (FWHM) through air at said distance of at least 100 mm;

sufficient for resolving through air at said distance of at least 100 mm under a Nema Bar Phantom test of gaps formed between 1 mm wide Lead bars positioned less than 6 mm apart from one another over a uniform cobalt disc; and

operative for image acquisition of said full organ in less than 10 seconds at said spatial resolution, capable of identifying objects not greater than about 6 mm×

6 mm×

6 mm with said signal-to-noise ratio of at least 4 to 1 or better.

51. The method of claim 43, wherein said sensitivity of said camera is selected from a group consisting of:

sufficient for reconstructing an image under a Cobalt wire Nema test of said line source of 5 mCi cobalt with a line spread function of less than 4 mm Full Width Half Maximum (FWHM) through air at said distance of at least 100 mm;

sufficient for resolving through air at said distance of at least 100 mm under a Nema Bar Phantom test of gaps formed between 1 mm wide Lead bars positioned less than 3 mm apart from one another over a uniform cobalt disc; and

operative for image acquisition of said full organ in less than 10 seconds at said spatial resolution, capable of identifying objects not greater than about 2 mm×

2 mm×

2 mm with said signal-to-noise ratio of at least 4 to 1 or better.

52. The method of claim 43, wherein said sensitivity of said camera is selected from a group consisting of:

sufficient for reconstructing an image under a Cobalt wire Nema test of said line source of 5 mCi cobalt with a line spread function of about 1 mm Full Width Half Maximum (FWHM) through air at said distance of at least 100 mm;

sufficient for resolving through air at said distance of at least 100 mm under a Nema Bar Phantom test of gaps formed between 1 mm wide led bars positioned less than 0.1 mm apart from one another over a uniform cobalt disc; and

operative for image acquisition of said full organ in less than 10 seconds at said spatial resolution, capable of identifying objects not greater than about 0.1 mm×

0.1 mm×

0.1 mm with said signal-to-noise ratio of at least 4 to 1 or better.

53. A method according to claim 1, wherein said viewing angle is at least 001 steradians.

54. A method according to claim 1, wherein said plurality of blocks comprises at least ten blocks with different viewing lines of sight.

55. A method according to claim 54, wherein each of said plurality of blocks is independently movable.

56. A method according to claim 1, wherein each block contains at least two detecting units.

57. A method according to claim 1, wherein said arranging comprising arranging said detecting units and said body in close proximity to each other.

58. A method according to claim 1, wherein said detecting units are located within a housing which does not move during said detection of single emissions.

59. A method according to claim 1, wherein said collimated detectors use non-parallel collimation.

60. A method according to claim 1, wherein said at least one collimator comprises and adjuster to adjust said viewing angle.

61. A method according to claim 1, wherein said at least one collimator as is a wide angle collimator having an angle wider than 90°

.

62. A method according to claim 1, wherein each said collimator is positioned to collimate radiation in front of multiple pixels of a detector.

63. A method according to claim 1, wherein each said collimator is positioned to collimate radiation in front of a single-pixel detector.

64. A method according to claim 1, wherein said at least one collimator is a narrow angle collimator having an angle narrower than 90°

.

65. A radioactive-emission-measurement system, comprising:

a camera for the detection of single emissions having at least three detecting blocks, the camera having a geometry such that said at least three detecting blocks detects at least 1 of every 5000 photons, emitted from at least one radioactive-emission source, located within a region-of-interest volume of at least 5×

5×

5 cm, wherein each said detecting block comprising one or more collimated solid-state ionizing radiation detecting units, each detecting unit including at least one pixel, each said detecting block has at least one collimator positioned in front of said at least one pixel, said at least one collimator substantially blocks gamma and beta radiation and defines a viewing angle of at least 0.005 steradians, said detecting blocks having different lines of sight and arranged to view said region of interest at a different orientation from others of said blocks; and

a data-processing system, configured for reconstructing a radioactive-emission SPECT image from detected photons under a Cobalt wire Nema test, said radioactive-emission SPECT image having a voxel size of 7 mm or less.