Tear film measurement

• US 8,591,033 B2
• Filed: 08/01/2011
• Issued: 11/26/2013
• Est. Priority Date: 06/20/2007
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Korb, Donald R., Gravely, Benjamin T.
• Primary Examiner(s): DANG, HUNG XUAN
• Application Number:
  US13/195,353
• Publication Number:
  US 20110285961A1
• Time in Patent Office: 848 Days
• Field of Search: 351/221, 351/246, 351/205, 351/200, 356/503, 600/476
• US Class Current: 351/221
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: G01B 11/0675 using interferometry

Abstract

The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient'"'"'s eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient'"'"'s head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient'"'"'s eye.

Claims

1. An apparatus for measuring the thickness of a tear film lipid layer on a surface of a patient'"'"'s eye, comprising:

an illuminator configured to direct light to the tear film lipid layer of the patient'"'"'s eye, the illuminator comprising a broad spectrum light source in a visible region being a lambertian emitter such that rays from the light source are specularly reflected from the tear film lipid layer; and

an imaging device configured to observe the specularly reflected light such that interference patterns of the specularly reflected light on the tear film lipid layer are observable.

2. The apparatus of claim 1, wherein the illuminator comprises an arcuate emitter.

3. The apparatus according to claim 2, wherein the arcuate emitter is constructed and arranged such that the light rays emitted therefrom strike the surface of the eye such that Snell'"'"'s Law is satisfied with respect to the acceptance angle of the imaging device produces an observable area of interference on the surface of the eye.

4. The apparatus according to claim 3, wherein the light rays that generate the observable area of interference are substantially normal to the surface of the eye.

5. The apparatus of claim 1, wherein the surface of the lambertian emitter is parallel or substantially parallel to the surface of the eye.

6. The apparatus of claim 1, wherein the imaging device comprises a hole defining an opening in the illuminator.

7. The apparatus according to claim 6, wherein the opening in the illuminator allows for observation of the specularly reflected light from behind the illuminator.

8. The apparatus according to claim 6, further including a collector for collecting and focusing the specularly reflected light and for generating an output signal representative thereof operatively associated with the opening.

9. The apparatus according to claim 8, further including a recording device for recording the output signal representative of the specularly reflected light.

10. The apparatus according to claim 9, wherein the recording device records in real time.

11. The apparatus according to claim 9, wherein the recording device is selected from the group of recording devices consisting of computer memory, video cassette recording devices, analog recording devices and digital recording devices.

12. The apparatus according to claim 8, wherein the collector comprises a camera lens system.

13. The apparatus according to claim 8, wherein the collector comprises a slit lamp.

14. The apparatus according to claim 1, wherein the specularly reflected light is observed when the patient'"'"'s head is positioned on an observation platform.

15. The apparatus according to claim 1, wherein the illuminator has a total radiated power of less than 1 W.

16. The apparatus of claim 1, wherein the illuminator is further configured to direct light to the tear film lipid layer of the patient'"'"'s eye such that rays from the light source undergo constructive and destructive interference in the tear film lipid layer.

17. The apparatus of claim 1, wherein the illuminator is configured to illuminate an area of approximately 2.5 mm by 5 mm on the tear film lipid layer of the patient'"'"'s eye.

18. The apparatus of claim 1, wherein the illuminator is configured to direct light to the tear film lipid layer of the patient'"'"'s eye, wherein the total light emitted from the surface of the illuminator is less that 10 μ

W/mm².

19. The apparatus of claim 1, wherein the

illuminator is further configured to direct light to the tear film lipid layer of the patient'"'"'s eye, wherein the illuminator illuminates the patient'"'"'s face, but wherein only an area below the pupil satisfies Snell'"'"'s law;

and

wherein the imaging device is further configured to observe the specularly reflected light such that interference patterns on the tear film lipid layer are observable in the area below the pupil with respect to an acceptance angle of the imaging device so as to produce an observable area of interference on the eye below the pupil.

20. The apparatus of claim 1, wherein the illuminator is further configured to illuminate an area of the patient'"'"'s eye and wherein the area having viewable interference fringes is located below the pupil.

21. The apparatus according to claim 20, wherein the area having the viewable interference fringes is an area of at least 12.5 mm².

22. The apparatus according to claim 1, wherein the illuminator has a total illumination intensity of less than that which would induce reflex tearing or cause a proprioceptive response to occur.

23. The apparatus according to claim 22, wherein the illuminator has a total illumination intensity of between about 1 μ

W/mm² and 15 μ

W/mm² at the surface of the illuminator.

24. The apparatus of claim 1, wherein the illuminator is further comprised of a uniform illumination lambertian emitter.