Biomimetic vascular network and devices using the same
First Claim
1. An artificial vascular layer comprising:
- a substrate defining a network of channels arranged in a radial pattern having at least one central output channel, a plurality of radially outward input channels, and a plurality of intermediate channels connecting the input channels and the at least one output channel, each channel having a height, a length, a width, and a diameter, wherein the intermediate channels undergo multiple branching and rejoining to form hexagonal areas intermediate to the intermediate channels,the intermediate channels being formed by varying said height and width with respect to adjacent portions of the channels and the length of a smallest of the intermediate channels is formed based on the respective diameter whereby said smallest intermediate channel has a biomimetic length.
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Accused Products
Abstract
The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
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Citations
17 Claims
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1. An artificial vascular layer comprising:
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a substrate defining a network of channels arranged in a radial pattern having at least one central output channel, a plurality of radially outward input channels, and a plurality of intermediate channels connecting the input channels and the at least one output channel, each channel having a height, a length, a width, and a diameter, wherein the intermediate channels undergo multiple branching and rejoining to form hexagonal areas intermediate to the intermediate channels, the intermediate channels being formed by varying said height and width with respect to adjacent portions of the channels and the length of a smallest of the intermediate channels is formed based on the respective diameter whereby said smallest intermediate channel has a biomimetic length. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An artificial vascular layer comprising:
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a substrate defining a network of channels arranged in a radial pattern having at least one central output channel, a plurality of radially outward input channels, and a plurality of intermediate channels connecting the input channels and the at least one output channel, each channel having a height, a length, a width, and a diameter, wherein the intermediate channels undergo multiple branching and rejoining to form hexagonal areas intermediate to the intermediate channels, the intermediate channels being formed by varying said height and width with respect to adjacent portions of the channels and the length of a smallest diameter of the intermediate channels is formed based on the respective diameter whereby said smallest diameter channel has a biomimetic length.
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17. An artificial vascular layer comprising:
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a substrate defining a network of channels arranged in a radial pattern having at least one central output channel, a plurality of radially outward input channels, and a plurality of intermediate channels connecting the input channels and the at least one output channel, each channel having a height, a length, a width, and a diameter, wherein the intermediate channels undergo multiple branching and rejoining to form hexagonal areas intermediate to the intermediate channels, the intermediate channels being formed by varying said height and width with respect to adjacent portions of the channels and the length of a smallest of the intermediate channels is formed based on the respective diameter whereby said smallest channel has a biomimetic length.
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Specification