Nicotine immunonanotherapeutics
First Claim
1. A composition comprising(1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of a plurality of nicotine moieties having the structure shown below or a metabolite thereof,
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Accused Products
Abstract
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
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Citations
25 Claims
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1. A composition comprising
(1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of a plurality of nicotine moieties having the structure shown below or a metabolite thereof,
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17. A method comprising administering a composition comprising
(1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of nicotine moieties having the structure shown below or a metabolite thereof,
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18. A method comprising administering a composition comprising
(1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of nicotine moieties having the structure shown below or a metabolite thereof,
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19. A method comprising administering to a subject an initial dose of a composition comprising
(1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of nicotine moieties having the structure shown below or a metabolite thereof,
Specification