Coatings of acrylamide-based copolymers
First Claim
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1. An implantable device comprising a coating, the coating comprising a conjugate of:
- a bioactive agent;
a linker comprising poly(ethylene glycol) (PEG), poly(alkylene oxide), C1-C12 alkyl, C3-C12 cycloalkyl, C3-12 aryl, a peptide, a peptide sequence, a protein, an oligomer of amino acids, succinic anhydride, glutaric anhydride, dimethyl succinic anhydride, methyl glutaric anhydride, a thioester, a disulfide bond, a polylactic acid oligomer, a poly(lactic-co-glycolic acid) oligomer, Polycaprolactone oligomer, an ester linkage, or an anhydride linkage; and
a copolymer of Formula II;
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Abstract
An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
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Citations
26 Claims
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1. An implantable device comprising a coating, the coating comprising a conjugate of:
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a bioactive agent; a linker comprising poly(ethylene glycol) (PEG), poly(alkylene oxide), C1-C12 alkyl, C3-C12 cycloalkyl, C3-12 aryl, a peptide, a peptide sequence, a protein, an oligomer of amino acids, succinic anhydride, glutaric anhydride, dimethyl succinic anhydride, methyl glutaric anhydride, a thioester, a disulfide bond, a polylactic acid oligomer, a poly(lactic-co-glycolic acid) oligomer, Polycaprolactone oligomer, an ester linkage, or an anhydride linkage; and a copolymer of Formula II; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of forming a coating on an implantable device, comprising:
providing a copolymer of Formula II; - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
Specification