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Dual controlled release dosage form

  • US 8,591,947 B2
  • Filed: 09/24/2012
  • Issued: 11/26/2013
  • Est. Priority Date: 11/06/2001
  • Status: Active Grant
First Claim
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1. A dual controlled release osmotic device consisting essentially of:

  • a bi-layered core consisting essentially of a controlled release active agent-containing first layer and a controlled release active agent-containing second layer, wherein the first and second layers are in intimate contact with one another and in stacked arrangement, and the osmotic device excludes a partition between the first layer and the second layer and excludes a push-layer; and

    a membrane enveloping the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing layers;

    whereby the osmotic device provides a controlled release of the first active agent through at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active agent through at least one preformed passageway according to a second release profile, andwherein the first and second active agents are independently selected at each occurrence from the group consisting of an antibiotic agent, antihistamine agent, decongestant, anti-inflammatory agent, antiparasitic agent, antiviral agent, local anesthetic, antifungal agent, amoebicidal agent, trichomonocidal agent, analgesic agent, anti-arthritic agent, anti-asthmatic agent, anticoagulant agent, anticonvulsant agent, anti-Alzheimer'"'"'s disease agent antidepressant agent, antidiabetic agent, antineoplastic agent, anti-psychotic agent, neuroleptic agent, antihypertensive agent, hypnotic agent, sedative agent, anxiolytic energizer agent, anti-Parkinson agent, muscle relaxant agent, antimalarial agent, hormonal agent, contraceptive agent, sympathomimetic agent, hypoglycemic agent, antilipemic agent, ophthalmic agent, electrolytic agent, diagnostic agent, prokinetic agent, gastric acid secretion inhibitor agent, anti-ulcerant agent, anti-flatulent agent, anti-incontinence agent, and cardiovascular agent.

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