Chondrocyte container and method of use
First Claim
1. A delivery device, comprising:
- a housing havinga cell chamber configured to retain a plurality of chondrocytes, the cell chamber having a length and a diameter, the length and the diameter each at least about 3 mm;
a portion of the housing configured to allow passage of a therapeutic agent produced via the chondrocytes;
an expandable chamber adjacent to the cell chamber, the expandable chamber separated from the cell chamber by a piston element; and
an auxiliary fluid chamber positioned between the cell chamber and the expandable chamber, the auxiliary fluid chamber configured to house an auxiliary fluid and the auxiliary fluid chamber separated from the cell chamber via a semi-permeable membrane.
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Accused Products
Abstract
Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).
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Citations
17 Claims
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1. A delivery device, comprising:
- a housing having
a cell chamber configured to retain a plurality of chondrocytes, the cell chamber having a length and a diameter, the length and the diameter each at least about 3 mm; a portion of the housing configured to allow passage of a therapeutic agent produced via the chondrocytes; an expandable chamber adjacent to the cell chamber, the expandable chamber separated from the cell chamber by a piston element; and an auxiliary fluid chamber positioned between the cell chamber and the expandable chamber, the auxiliary fluid chamber configured to house an auxiliary fluid and the auxiliary fluid chamber separated from the cell chamber via a semi-permeable membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- a housing having
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17. A delivery device, comprising:
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a cell chamber configured to retain a plurality of chondrocytes, the cell chamber further configured to allow for the release of a therapeutic agent produced by the chondrocytes, wherein the cell chamber is sized such that a portion of the chondrocytes are a distance of at least about 1.5 mm from an outer wall of the device; an expandable chamber adjacent to the cell chamber, the expandable chamber separated from the cell chamber by a piston element; and an auxiliary fluid chamber positioned between the cell chamber and the expandable chamber, the auxiliary fluid chamber configured to house an auxiliary fluid and the auxiliary fluid chamber separated from the cell chamber via a semi-permeable membrane.
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Specification