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Surface-enhanced raman nanobiosensor

  • US 8,592,226 B2
  • Filed: 09/09/2009
  • Issued: 11/26/2013
  • Est. Priority Date: 08/30/2002
  • Status: Active Grant
First Claim
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1. A method for the in vivo determination of glucose concentration, comprising:

  • a) contacting an implanted biosensor with a bodily fluid to create a biosensor-glucose ensemble;

    i) wherein said bodily fluid comprises glucose,ii) wherein said implanted biosensor comprises,1. a substrate,2. nanospheres, said nanospheres in contact with said substrate,3. a metal film, said metal film formed over said nanospheres, and4. a self-assembled mixed partition layer, said self-assembled mixed partition layer adhered to said metal film, said self-assembled mixed partition layer comprising at least two discrete compounds,a. said two discrete compounds comprising decanethiol and mercaptohexanol, andiii) wherein said glucose concentrates within the self-assembled mixed partition layer in close physical proximity to the metal film;

    b) directly detecting said glucose in said biosensor-glucose ensemble with surface-enhanced Raman spectroscopy to create a surface-enhanced Raman signal; and

    c) correlating said surface-enhanced Raman signal to the concentration of said glucose in said bodily fluid.

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