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Immunostimulatory oligonucleotides and use thereof in pharmaceuticals

  • US 8,592,566 B2
  • Filed: 05/31/2007
  • Issued: 11/26/2013
  • Est. Priority Date: 05/31/2006
  • Status: Expired due to Fees
First Claim
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1. An artificial immunostimulatory oligonucleotide comprising:

  • the nucleotide sequence represented by the formula;

    5′

    -(G)MPXCGYQ(G)N-3′

    (SEQ ID NO.;

         117) wherein,C is cytosine;

    G is guanine;

    X and Y are mutually independent and each represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive guanine residues, and the entire length of X+Y is 6 to 20 nucleotides;

    XCGY contains a palindrome sequence having a length of at least 8 nucleotides and XCGY has a length of 8 to 22 nucleotides;

    P and Q are mutually independent and each represent one nucleotide other than guanine,M represents an integer of 6 to 10,N represents an integer of 0 to 3;

    and the length of X and Y may be the same or different, andwherein the length of the artificial immunostimulatory oligonucleotide is 16 to 37 nucleotides in total,wherein the palindrome sequence contains CGATCG (SEQ ID NO;

         59), ATCGAT (SEQ ID NO;

         60), or GACGTC (SEQ ID NO;

         61),but the artificial immunostimulatory nucleotide is not SEQ ID NO;

    5 GGGGGGTGCCGATCGGCAGGG.

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