Component concentration meter, component concentration measurement method, shipping inspection system, and health management system

• US 8,592,769 B2
• Filed: 12/10/2010
• Issued: 11/26/2013
• Est. Priority Date: 12/18/2009
• Status: Expired due to Fees

• Current Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: Kusukame, Koichi, Kadowaki, Shinichi, Furuya, Hiroyuki
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): GUNBERG, EDWIN C
• Application Number:
  US13/201,637
• Publication Number:
  US 20110299066A1
• Time in Patent Office: 1,082 Days
• Field of Search: 250/341.6, 600/319
• US Class Current: 250/341.6
• CPC Class Codes: G01N 21/19 Dichroism
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/3563 for analysing solids; Preparation of samples therefor
• CPC Class Codes: G01N 21/3581 using far infrared light; using Terahertz radiation
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

An component concentration meter includes an output unit that outputs an electromagnetic wave to an object to be measured and includes a detecting unit that detects the property of the electromagnetic wave passed through the object to be measured under a first condition and under a second condition in which the temperature of the object to be measured is different from that under the first condition. The component concentration meter also includes a concentration determining unit that determines the concentration of a target component contained in the object to be measured, based on a property difference which is a difference between the properties of the electromagnetic wave detected by the detecting unit under the first condition and under the second condition and a difference between the temperatures of the object to be measured under the first condition and under the second condition.

Claims

1. A component concentration meter that measures a concentration of a target component contained in an object to be measured, the component concentration meter comprising:

an output unit configured to output an electromagnetic wave to the object to be measured;

a detecting unit configured to detect a property of the electromagnetic wave passed through the object to be measured under a first condition and under a second condition in which a temperature of the object to be measured is different; and

a concentration determining unit configured to determine the concentration of the target component contained in the object to be measured, based on (i) a property difference which is a difference between a property of the electromagnetic wave detected by said detecting unit under the first condition and a property of the electromagnetic wave detected by said detecting unit under the second condition, and (ii) a difference between the temperature of the object to be measured under the first condition and the temperature of the object to be measured under the second condition,

wherein said output unit is configured to output an electromagnetic wave for detection that has a first wavelength and passes through the object to be measured to be detected by said detecting unit and to output an electromagnetic wave for heating that has a second wavelength and is absorbed by the object to be measured to increase the temperature of the object to be measured,

wherein the electromagnetic wave for heating has an absorption by the object to be measured that is larger than an absorption of the electromagnetic wave for detection, and

wherein the difference between the temperature of the object to be measured under the first condition and the temperature of the object to be measured under the second condition is caused by said output unit outputting the electromagnetic wave for heating to the object to be measured.

2. The component concentration meter according to claim 1, wherein the electromagnetic wave for detection has a property that significantly changes according to a change of the temperature of the object to be measured compared to the electromagnetic wave for heating.

3. The component concentration meter according to claim 1, wherein said detecting unit is configured to detect the property of the electromagnetic wave passed through the object to be measured under the first condition in which a first electromagnetic wave pulse is output from said output unit and under the second condition in which a second electromagnetic wave pulse having a different pulse energy from a pulse energy of the first electromagnetic wave pulse is output from said output unit.

4. The component concentration meter according to claim 3, wherein said output unit is configured to output the first and second electromagnetic wave pulses each having a different pulse energy by varying a peak power between the first and second electromagnetic wave pulses.

5. The component concentration meter according to claim 3, wherein said output unit is configured to output the first and second electromagnetic wave pulses each having a different pulse energy by varying an irradiation time between the first and second electromagnetic wave pulses.

6. The component concentration meter according to claim 1,

wherein the target component is glucose, and

wherein said output unit is configured to output the electromagnetic wave for detection having the first wavelength selected from (i) a range of not less than 1600 nm and not more than 1900 nm, (ii) a range of not less than 900 nm and not more than 1050 nm, or (iii) a range of not less than 1200 nm and not more than 1270 nm.

7. The component concentration meter according to claim 1,

wherein the object to be measured contains moisture, and

wherein said output unit is configured to output the electromagnetic wave for detection having the first wavelength selected from (i) a range of not less than 1100 nm and not more than 1180 nm or (ii) a range of not less than 900 nm and not more than 990 nm.

8. The component concentration meter according to claim 1,

wherein the object to be measured includes a biological cell, and

wherein said output unit is configured to output the electromagnetic wave for heating having a pulse width of not less than 10 ns and not more than 1 μ

s.

9. The component concentration meter according to claim 1,

wherein the object to be measured is an anterior aqueous humor in an eye,

wherein said component concentration meter further includes a cylindrical body having a bottom and an opening on a top surface of said cylindrical body, and holding a protection solution having a higher refractive index than a refractive index of the anterior aqueous humor in the eye within the cylindrical body having the bottom,

wherein said output unit is provided on a side surface of said cylindrical body having the bottom so as to output an electromagnetic wave passing through the protection solution to the opening, and

wherein said detecting unit is provided on the side surface of said cylindrical body having the bottom so as to detect a property of the electromagnetic wave that enters from the opening and passes through the protection solution.

10. The component concentration meter according to claim 9, wherein the surface of said cylindrical body having the bottom is light-shielded.

11. The component concentration meter according to claim 1, further comprising an electromagnetic wave converging unit configured to converge the electromagnetic wave output from said output unit, and provided in an electromagnetic wave propagation path between said output unit and the object to be measured.

12. The component concentration meter according to claim 1, further comprising a storing unit configured to store an association table that holds the property difference, the difference in the temperature, and the concentration of the target component in association,

wherein said concentration determining unit is configured to determine the concentration of the target component corresponding to the property difference and the difference in the temperature detected by said detecting unit with reference to the association table held in said storing unit.

13. The component concentration meter according to claim 1, further comprising a smoothing material that smoothes depressions and projections of the object to be measured in order to provide a uniform distribution of intensity of an electromagnetic wave in a propagation path from said output unit to said detecting unit.

14. The component concentration meter according to claim 1, comprising a polarized wave separating unit configured to extract a predetermined polarization component contained in the electromagnetic wave passed through the object to be measured,

wherein said detecting unit is configured to detect a degree of optical rotation of the polarization component extracted by said polarized wave separating unit under the first condition and under the second condition, and

wherein said concentration determining unit is configured to determine the concentration of the target component contained in the object to be measured, based on the difference in the temperature and a difference in the degree of optical rotation.

15. The component concentration meter according to claim 1,

wherein said output unit is configured to output an electromagnetic wave having a first wavelength and an electromagnetic wave having a second wavelength, and

wherein said component concentration meter further comprises:

a synthesizing unit configured to synthesize the electromagnetic wave having the first wavelength with the electromagnetic wave having the second wavelength and to output the synthesized electromagnetic wave to the object to be measured; and

a separating unit configured to separate the electromagnetic wave passed through the object to be measured into the electromagnetic wave having the first wavelength and the electromagnetic wave having the second wavelength.

16. The component concentration meter according to claim 1, wherein said output unit includes:

an oscillating unit configured to oscillate an electromagnetic wave having a first wavelength; and

a wavelength converting unit configured to convert part of the electromagnetic wave oscillated by said oscillating unit into an electromagnetic wave having a second wavelength that is different from the first wavelength.

17. A component concentration measurement method that measures a concentration of a target component contained in an object to be measured, the component concentration measurement method comprising:

outputting an electromagnetic wave to the object to be measured;

detecting a property of the electromagnetic wave passed through the object to be measured under a first condition and under a second condition in which a temperature of the object to be measured is different; and

determining the concentration of the target component contained in the object to be measured, based on (i) a property difference which is a difference between a property of the electromagnetic wave detected in said detecting under the first condition and a property of the electromagnetic wave detected in said detecting under the second condition, and (ii) a difference between the temperature of the object to be measured under the first condition and the temperature of the object to be measured under the second condition,

wherein said outputting further outputs an electromagnetic wave for detection that has a first wavelength and passes through the object to be measured to be detected by said detecting and outputs an electromagnetic wave for heating that has a second wavelength and is absorbed by the object to be measured to increase the temperature of the object to be measured,

wherein the electromagnetic wave for heating has an absorption by the object to be measured that is larger than an absorption of the electromagnetic wave for detection, and

wherein the difference between the temperature of the object to be measured under the first condition and the temperature of the object to be measured under the second condition is caused by said outputting performing the outputting of the electromagnetic wave for heating to the object to be measured.