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Context driven image mining to generate image-based biomarkers

  • US 8,594,410 B2
  • Filed: 01/18/2011
  • Issued: 11/26/2013
  • Est. Priority Date: 08/28/2006
  • Status: Active Grant
First Claim
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1. A method comprising:

  • acquiring pixel values of medical images of patients;

    generating objects of a data network for each of the medical images by linking selected pixel values to selected objects according to a class network and a process hierarchy;

    measuring the objects to obtain a value for each of a plurality of image features;

    selecting a first subset of the image features that belong to a first image-based biomarker;

    correlating the first image-based biomarker for each of the patients with a clinical endpoint observed for that patient;

    displaying on a graphical user interface how the first image-based biomarker correlates with the clinical endpoint observed for each of the patients;

    identifying a subgroup of the patients for which the first image-based biomarker correlates poorly with the clinical endpoints observed for the patients in the subgroup; and

    selecting a second subset of the image features that belong to a second image-based biomarker that better correlates with the clinical endpoints observed for the patients in the subgroup.

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