Transmission fluorometer
First Claim
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1. A non-invasive measurement system for determining ratios of concentrations of at least two analytes in a sample area, the system comprising:
- a light source configured to provide an output spectrum which excites the at least two analytes at each of a plurality of discrete locations within a sample area;
an image sensing assembly capable of sensing the intensity and wavelength of fluoresced light emitted by the at least two analytes upon excitation by the light source at each of the plurality of discrete locations within the sample area; and
a computer system linked to the image sensing assembly, the computer system comprising computer readable code for computing and providing as output the ratio of the concentration of one analyte relative to the concentration of at least another analyte for each of the plurality of discrete locations within the sample area.
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Abstract
This disclosure relates generally to a system and method for noninvasive, non-destructive fluorescent measurement. More specifically, the disclosure provides a non-invasive metrology system and method to monitor levels of fluorescent chemicals in the blood. A major application for the invention is field-based non-invasive blood testing for micro-nutrient deficiency and diseases resulting from it, such as Iron deficient anemia. The invention may help reduce or eliminate the need for blood drawing, sending the sample to a blood lab and having to wait for a result.
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Citations
29 Claims
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1. A non-invasive measurement system for determining ratios of concentrations of at least two analytes in a sample area, the system comprising:
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a light source configured to provide an output spectrum which excites the at least two analytes at each of a plurality of discrete locations within a sample area; an image sensing assembly capable of sensing the intensity and wavelength of fluoresced light emitted by the at least two analytes upon excitation by the light source at each of the plurality of discrete locations within the sample area; and a computer system linked to the image sensing assembly, the computer system comprising computer readable code for computing and providing as output the ratio of the concentration of one analyte relative to the concentration of at least another analyte for each of the plurality of discrete locations within the sample area. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification