Device and method for assessing the electrical potential of cells and method for manufacture of same
First Claim
1. A system for assessing the clinically significant electrical potential created by static and quasi-static electromagnetic fields of cells in a living organism, comprising:
- a high-density array of passive sensor electrodes having a selectable spacing including at least one geometrically repeated pattern of sensor electrodes, whereby a uniform sensor electrode distribution overlays a region of interest on a surface of a living organism containing cells of clinical interest proximal to at least some of the sensor electrodes, and formed with a conductive electrolyte overlying each sensor electrode in the high-density array; and
a quasi-static DC electrical potential measurement device configured to make measurements of an electrical potential at each sensor electrode of the high-density array on a measurement surface in the first region of interest;
a processor configured to take a first measurement of an electrical potential of each electrode of the high-density array, take a second measurement of an electrical potential as a reference, determine a variability of the first measurement of the electrodes, set a normal control for mean values across the high-density array, and perform a convolution of each measurement at each location of the array, by averaging each array measurement with itself and its nearest neighbors wherein the processor performs the convolution at least three times.
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Abstract
An apparatus and processing method for assessing the electrical potential of cells in a living organism using a high-density sensor array having a density of at least about 9 electrodes per square inch for measuring the potential of the static and quasi-static electromagnetic fields of the group of cells proximal to each electrode, where the array can be placed overlying at least a portion of a surface of a living organism with substantially all of the electrodes electrically contactable with such surface, and the surface overlying a site containing cells of clinical interest.
57 Citations
46 Claims
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1. A system for assessing the clinically significant electrical potential created by static and quasi-static electromagnetic fields of cells in a living organism, comprising:
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a high-density array of passive sensor electrodes having a selectable spacing including at least one geometrically repeated pattern of sensor electrodes, whereby a uniform sensor electrode distribution overlays a region of interest on a surface of a living organism containing cells of clinical interest proximal to at least some of the sensor electrodes, and formed with a conductive electrolyte overlying each sensor electrode in the high-density array; and a quasi-static DC electrical potential measurement device configured to make measurements of an electrical potential at each sensor electrode of the high-density array on a measurement surface in the first region of interest; a processor configured to take a first measurement of an electrical potential of each electrode of the high-density array, take a second measurement of an electrical potential as a reference, determine a variability of the first measurement of the electrodes, set a normal control for mean values across the high-density array, and perform a convolution of each measurement at each location of the array, by averaging each array measurement with itself and its nearest neighbors wherein the processor performs the convolution at least three times. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification