Reducing inappropriate delivery of therapy for suspected non-lethal arrhythmias

• US 8,594,786 B2
• Filed: 03/22/2011
• Issued: 11/26/2013
• Est. Priority Date: 01/08/2004
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ousdigian, Kevin T.
• Primary Examiner(s): DIETRICH, JOSEPH M
• Application Number:
  US13/053,625
• Publication Number:
  US 20110172727A1
• Time in Patent Office: 980 Days
• Field of Search: 600515-518, 607/14, 607/15
• US Class Current: 607/14
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
• CPC Class Codes: A61N 1/3987 characterised by the timing or triggering of the shock

Abstract

An implantable medical device (IMD) identifies suspected non-lethal ventricular arrhythmia, and takes one or more actions in response to the identification to avoid or delay delivery of a defibrillation or cardioversion shock. The IMD employs number of intervals to detect (NID) thresholds for detection of ventricular arrhythmias. When a NID threshold is met, the IMD determines whether the ventricular rhythm is a suspected non-lethal rhythm despite satisfying a NID threshold. In some embodiments, the IMD increases the NID threshold, i.e., extends the time for detection, in response to identifying a rhythm as a suspected non-lethal rhythm, and monitors subsequent ventricular beats to determine if the increased NID threshold is met before detecting a ventricular arrhythmia and delivering therapy. The IMD can determine whether a rhythm is a suspected non-lethal arrhythmia by, for example, comparing the median ventricular cycle length (VCL) to the median atrial cycle length (ACL).

Claims

1. A method comprising:

measuring ventricular cycle lengths within a ventricular rhythm;

determining a number of times within a time period that the measured ventricular cycle lengths fall within a ventricular cycle length zone associated with an arrhythmia;

determining that a number of intervals to detect (NID) threshold for a ventricular arrhythmia is met based on the determined number of times that measured ventricular cycle lengths fall within a ventricular cycle length zone during the time period;

determining that the ventricular arrhythmia is a suspected non-lethal arrhythmia subsequent to the determination that the NID threshold is met; and

changing a ventricular therapy scheduled for the arrhythmia based on the determination that the rhythm is a suspected non-lethal arrhythmia.

2. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises determining that the ventricular rhythm is one of a suspected supraventricular tachycardia and a monomorphic ventricular tachycardia.

3. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises:

comparing a ventricular cycle length to an atrial cycle length, wherein the ventricular and atrial cycle lengths are one of median and mean cycle lengths; and

determining that the ventricular rhythm is a suspected non-lethal arrhythmia based on the comparison.

4. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises determining that a ventricular cycle length exceeds a minimum ventricular cycle length threshold, and the ventricular cycle length is one of a median and a mean ventricular cycle length.

5. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises analyzing at least one of regularity of the ventricular cycle lengths, regularity of a morphological feature of the ventricular rhythm, A:

V association, and rate of onset of at least one of atrial cycle lengths, ventricular cycle lengths, and A-V interval lengths.

6. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises analyzing one of an intracardiac pressure, respiration, and an activity level of a patient.

7. The method of claim 1, wherein the scheduled therapy comprises one of a sequence of defibrillation shocks and a sequence of cardioversion shocks, and changing the scheduled therapy comprises one of reducing a number of shocks in the sequence and replacing at least one of the shocks of the sequence with at least one anti-tachycardia pacing attempt.

8. The method of claim 1, wherein the scheduled therapy comprises a sequence of anti-tachycardia pacing attempts, and changing the scheduled therapy comprises one of canceling the anti-tachycardia pacing attempts, reducing a number of the anti-tachycardia pacing attempts, and increasing the number of the anti-tachycardia pacing attempts.

9. The method of claim 1, wherein changing a scheduled therapy for the arrhythmia in response to the determination that the ventricular rhythm is a suspected non-lethal arrhythmia comprises applying a first change to the scheduled therapy, the method further comprising:

determining that the ventricular rhythm is a slow suspected non-lethal arrhythmia; and

applying a second change to the scheduled therapy based on the determination.

10. The method of claim 9, wherein applying a second change comprises applying the second change instead of the first change.

11. The method of claim 9, wherein applying a second change comprises canceling the scheduled therapy.

12. The method of claim 1, wherein determining that the ventricular rhythm is a suspected non-lethal arrhythmia comprises identifying at least one of cardiac and non-cardiac oversensing.

13. The method of claim 12, wherein identifying at least one of cardiac and non-cardiac oversensing comprises determining that one of a median ventricular cycle length and a mean ventricular cycle length is less than or equal to an oversensing threshold value.

14. The method of claim 1, further comprising delivering the changed scheduled therapy to ventricles of a heart.

15. The method of claim 1, further comprising:

increasing the NID threshold based on the determination that the rhythm is a suspected non-lethal arrhythmia; and

measuring subsequent ventricular cycle lengths; and

determining that the increased NID threshold is met, wherein delivering the changed scheduled therapy comprises delivering the changed scheduled therapy to the ventricles upon determining that the increased NID threshold is met.

16. The method of claim 1, further comprising delivering anti-tachycardia pacing therapy to atria of a heart based on the determination that the rhythm is a suspected non-lethal arrhythmia.

17. The method of claim 1, wherein determining that the NID threshold for a ventricular arrhythmia is met based on the determined number of times that measured ventricular cycle lengths fall within a ventricular cycle length zone during the time period comprises at least one of:

determining that the NID threshold for a ventricular arrhythmia is met when the determined number of times that the measured ventricular cycle lengths fall within the ventricular cycle length zone is greater than or equal to a threshold number,

determining that the NID threshold for a ventricular arrhythmia is met when the consecutive number of the measured ventricular cycle lengths that fall within a ventricular cycle length zone during the time period is greater than or equal to a threshold number, or

determining that the NID threshold for a ventricular arrhythmia is met when a particular fraction of the measured ventricular cycle lengths fall within a ventricular cycle length zone during the time period.

18. An implantable medical device comprising:

electrodes to detect depolarizations of at least one ventricle of a heart;

a processor that receives the detected depolarizations and is configured to measure ventricular cycle lengths within a ventricular rhythm, determine a number of times within a time period that the measured ventricular cycle lengths fall within a ventricular cycle length zone associated with an arrhythmia, determine that a number of intervals to detect (NID) threshold for a ventricular arrhythmia is met based on the determined number of times that measured ventricular cycle lengths fall within a ventricular cycle length zone during the time period, determine that the ventricular arrhythmia is a suspected non-lethal arrhythmia subsequent to the determination that the NID threshold is met and change a ventricular therapy scheduled for the arrhythmia based on the determination that the rhythm is a suspected non-lethal arrhythmia.

19. The device of claim 18, wherein the processor determines that the ventricular rhythm is a suspected non-lethal arrhythmia when it detects a suspected supraventricular tachycardia and a monomorphic ventricular tachycardia.

20. The device of claim 18, wherein the processor compares a ventricular cycle length to an atrial cycle length, wherein the ventricular and atrial cycle lengths are one of median and mean cycle lengths and determines that the ventricular rhythm is a suspected non-lethal arrhythmia based on the comparison.

21. The device of claim 18, wherein the processor determines that the ventricular rhythm is a suspected non-lethal arrhythmia when a ventricular cycle length exceeds a minimum ventricular cycle length threshold, and the ventricular cycle length is one of a median and a mean ventricular cycle length.

22. The device of claim 18, wherein the processor determines that the ventricular rhythm is a suspected non-lethal arrhythmia based on an analysis of at least one of regularity of the ventricular cycle lengths, regularity of a morphological feature of the ventricular rhythm, A:

V association, and rate of onset of at least one of atrial cycle lengths, ventricular cycle lengths, and A-V interval lengths.

23. The device of claim 18, wherein the processor determines that the ventricular rhythm is a suspected non-lethal arrhythmia based on analysis of at least one of an intracardiac pressure, respiration, and an activity level of a patient.

24. The device of claim 18, wherein the scheduled therapy comprises one of a sequence of defibrillation shocks and a sequence of cardioversion shocks, and the processor changes the scheduled therapy by one of reducing a number of shocks in the sequence and replacing at least one of the shocks of the sequence with at least one anti-tachycardia pacing attempt.

25. The device of claim 18, wherein the scheduled therapy comprises a sequence of anti-tachycardia pacing attempts, and the processor changes the scheduled therapy by one of canceling the anti-tachycardia pacing attempts, reducing a number of the anti-tachycardia pacing attempts, and increasing the number of the anti-tachycardia pacing attempts.

26. The device of claim 18, wherein the processor changes applies a first change to change the scheduled therapy, determines that the ventricular rhythm is a slow suspected non-lethal arrhythmia and applies a second change to the scheduled therapy based on the determination.

27. The device of claim 26, wherein the processor applies the second change by canceling the scheduled therapy.

28. The device of claim 18, wherein the processor determines that the ventricular rhythm is a suspected non-lethal arrhythmia by identifying at least one of cardiac and non-cardiac oversensing.

29. The device of claim 28, wherein the processor identifies at least one of cardiac and non-cardiac oversensing when one of a median ventricular cycle length and a mean ventricular cycle length is less than or equal to an oversensing threshold value.

30. The device of claim 18, wherein the processor delivers the changed scheduled therapy to ventricles of a heart via one or more of the electrodes.

31. The device of claim 18, further comprising a memory to store a number of intervals to detect (NID) threshold for a ventricular arrhythmia, wherein the processor increases the NID threshold based on the determination that the rhythm is a suspected non-lethal arrhythmia, measures subsequent ventricular cycle lengths;

and determines determining that the increased NID threshold is met, wherein delivering the changed scheduled therapy comprises delivering the changed scheduled therapy to the ventricles upon determining that the increased NID threshold is met.

32. The device of claim 18, wherein the processor delivers anti-tachycardia pacing therapy to atria of a heart via one or more of the electrodes based on the determination that the rhythm is a suspected non-lethal arrhythmia.

33. The device of claim 18, wherein the processor is configured determine that the NID threshold for a ventricular arrhythmia is met when at least one of

the determined number of times that the measured ventricular cycle lengths fall within the ventricular cycle length zone is greater than or equal to a threshold number,

a consecutive number of the measured ventricular cycle lengths that fall within a ventricular cycle length zone during the time period is greater than or equal to a threshold number, or

a particular fraction of the measured ventricular cycle lengths fall within a ventricular cycle length zone during the time period.