Coating of fast absorption or dissolution

• US 8,597,673 B2
• Filed: 12/13/2006
• Issued: 12/03/2013
• Est. Priority Date: 12/13/2006
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Trollsas, Mikael O., Ngo, Michael Huy, Maslanka, Bozena Zofia, Hossainy, Syed Faiyaz Ahmed, Kleiner, Lothar W.
• Primary Examiner(s): Heyer, Dennis
• Application Number:
  US11/638,780
• Publication Number:
  US 20080145393A1
• Time in Patent Office: 2,547 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C09D 143/02 Homopolymers or copolymers of monomers containing phosphorus
• CPC Class Codes: Y10T 428/263 Coating layer not in excess of 5 mils thick or equivalent

Abstract

A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.

Claims

1. A coating on an implantable device, the coating comprising a phosphoryl choline polymer, wherein about 50 wt % or more of the coating can absorb or dissolve within 24 hours after implantation,

wherein the phosphoryl choline polymer comprises at least one phosphoryl choline moiety and at least one moiety derived from a biocompatible polymer,

wherein the biocompatible polymer comprises poly(ester amide), poly(lactic acid), poly(glycolic acid), poly(caprolactone), poly(dioxanone), or poly(ester amide-2,2,6,6-tetramethyl-1-piperidinyloxy) (PEA-TEMPO),

wherein phosphoryl choline polymer comprises a fragment having the formula of

2. The coating of claim 1, wherein the fragment of Formula X has a Mw of 5000 Daltons or below.

3. The coating of claim 1, wherein n and m are each about 0.5.

4. The coating of claim 1, wherein the phosphoryl choline polymer is random or block copolymer.

5. The coating of claim 1, further comprising a bioactive agent.

6. The coating of claim 5, wherein the bioactive agent is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, 4 amino-2,2,6,6-tetramethyl piperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), pimecrolimus, imatinib mesylate, midostaurin, clobetasol, mometasone, CD-34 antibody, abciximab (REOPRO), progenitor cell capturing antibody, prodrugs thereof, or a combination thereof.

7. The coating of claim 1, wherein the implantable device is a stent.

8. A method of treating a disorder in a human being by implanting in the human being an implantable device comprising the coating of claim 1, wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.