HBV antisense inhibitors
First Claim
1. An antisense compound comprising a single-stranded modified antisense oligonucleotide consisting of 16 nucleotides having a contiguous nucleoside sequence, wherein nucleotides in the oligonucleotide are connected by internucleotide linkages and wherein the nucleoside sequence is selected from the group consisting of SEQ ID NO:
- 14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, and SEQ ID NO;
22 wherein at least one nucleotide comprises a modified sugar.
5 Assignments
0 Petitions
Accused Products
Abstract
Antisense oligomers useful for modulating hepatitis B virus infections, and for the treatment of hepatitis B virus (HBV) and hepatitis B virus-related conditions in animals including humans. More particularly, antisense oligomers with modified nucleotides for treatment of HBV in animals, more particularly antisense oligomers comprising 2′O-4′C-methylene-bridged sugars, or nucleotides with other 2′O-4′C bridged sugars, also known as locked nucleic acids (LNA), for treatment of HBV in animals, and more particularly for treatment of HBV in humans.
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Citations
35 Claims
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1. An antisense compound comprising a single-stranded modified antisense oligonucleotide consisting of 16 nucleotides having a contiguous nucleoside sequence, wherein nucleotides in the oligonucleotide are connected by internucleotide linkages and wherein the nucleoside sequence is selected from the group consisting of SEQ ID NO:
- 14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, and SEQ ID NO;
22 wherein at least one nucleotide comprises a modified sugar. - View Dependent Claims (2, 3, 4, 5, 9, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- 14, SEQ ID NO;
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6. An antisense compound comprising a single-stranded modified antisense oligonucleotide consisting of 16 nucleotides having a contiguous nucleoside sequence wherein nucleotides in the oligonucleotide are connected by internucleotide linkages, and wherein the nucleoside sequence is essentially complementary to a sequence selected from the group consisting of SEQ ID NO:
- 1;
SEQ ID NO;
2;
SEQ ID NO;
3;
SEQ ID NO;
4;
SEQ ID NO;
5;
SEQ ID NO;
6;
SEQ ID NO;
7;
SEQ ID NO;
8;
SEQ ID NO;
9;
SEQ ID NO;
10;
SEQ ID NO;
11;
SEQ ID NO;
12; and
SEQ ID NO;
13. - View Dependent Claims (7, 8, 10, 11)
- 1;
Specification