Multi-axis/multi-field charged particle cancer therapy method and apparatus

• US 8,598,543 B2
• Filed: 01/05/2011
• Issued: 12/03/2013
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): MASKELL, MICHAEL P
• Application Number:
  US12/985,039
• Publication Number:
  US 20110118529A1
• Time in Patent Office: 1,063 Days
• Field of Search: 250/396.R, 250/492.1, 250/492.3, 313/62, 315/503, 315/504
• US Class Current: 250/492.1
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention relates to a method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field raster beam charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, beam movement velocity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.

Claims

1. An apparatus configured to control a charged particle raster beam for irradiation of a tumor of a patient, comprising:

a charged particle beam system comprising a particle beam controller configured to;

scan the charged particle raster beam from position to position in the tumor without turning off the charged particle raster beam;

simultaneously control multi-field rotation of the patient; and

simultaneously control multi-axis targeting of the charged particle raster beam.

2. The apparatus of claim 1, said control of multi-field rotation further comprising control of:

a fixed orientation proton source; and

a rotating platform supporting the patient.

3. The apparatus of claim 2, said control of multi-axis targeting further comprising control of:

a velocity control system, said velocity control system variably altering a rate of scanning movement of the charged raster beam while the raster beam continuously provides protons.

4. The apparatus of claim 3, said particle beam controller configured to:

control an intensity controller, said intensity controller configured to use a measure of a current, resulting from the charged particle raster beam striking an extraction foil, as a feedback control to a radio-frequency cavity system.

5. The apparatus of claim 2, said control of multi-axis targeting configured to change an x, y, and z-axis position of a spot of the raster beam with a first velocity, wherein the first velocity is adjusted to a second velocity while the raster beam continuously provides charged particles.

6. The apparatus of claim 5, said particle beam controller further configured to:

vary energy level of the charged particle raster beam simultaneous with;

rotation of the rotating platform; and

movement of a spot of the raster beam in three-dimensional space.

7. The apparatus of claim 5, said particle beam controller further configured to vary flux of the raster beam simultaneous with said scanning of the charged particle raster beam from position to position in the tumor without turning off the charged particle raster beam.

8. The apparatus of claim 1, said particle beam controller further configured to:

simultaneously vary flux of the charged particle raster beam.

9. The apparatus of claim 1, said particle beam controller configured to coordinate with patient respiration all of:

rotation of the patient relative to a fixed orientation proton source;

changing velocity of movement of a spot of the raster beam;

varying energy of the raster beam; and

varying intensity of the raster beam.

10. An apparatus configured to control a charged particle raster beam for irradiation of a tumor of a patient, comprising:

a charged particle beam system comprising a particle beam controller configured to;

scan the charged particle raster beam from position to position in the tumor without turning off the charged particle raster beam; and

simultaneously control multi-field rotation of the patient.

11. The apparatus of claim 10, said charged particle beam system comprising a synchrotron, said synchrotron comprising a gap configured to circumferentially surround a portion of the charge particle raster beam, said gap proximate a magnet, said gap comprising a vertical size of less than four centimeters and a horizontal size of less than nine centimeters.

12. The apparatus of claim 10, further comprising:

a synchrotron configured to accelerate the raster beam, said synchrotron comprising a gap of about two centimeters by about five to six centimeters through which the raster beam circulates during acceleration.

13. The apparatus of claim 12, the gap traversing exactly four turning sections, each of said four turning sections comprising at least four non-quadrupole magnets.

14. The apparatus of claim 10, further comprising, simultaneous with said scanning of the charged particle raster beam from position to position in the tumor without turning off the charged particle raster beam, at least two of:

a beam energy controller configured to vary energy of the raster beam;

a beam intensity controller configured to vary intensity of the raster beam;

a beam velocity controller configured to vary velocity of the raster beam.

15. An apparatus configured to control a charged particle raster beam for irradiation of a tumor of a patient, comprising:

a charged particle beam system comprising a particle beam controller configured to;

scan the charged particle raster beam from position to position in the tumor without turning off the charged particle raster beam; and

simultaneously control multi-axis targeting of the charged particle raster beam.

16. The apparatus of claim 15, further comprising a synchrotron configured to accelerate the beam, said synchrotron further comprising:

a radio-frequency field generator, wherein during use said radio-frequency generator applies a radio-frequency field to the circulating charged particles yielding betatron oscillating charged particles;

an extraction material, wherein at least a portion of the betatron oscillating charged particles pass through said extraction material resulting in a secondary emission electron flow;

an intensity sensor, said intensity sensor determining a measure of said electron flow; and

a feedback control loop comprising an intensity controller, wherein said intensity controller provides said measure of electron flow as a feedback to said radio-frequency generator,

wherein said feedback control loop controls intensity of charged particles extracted from said synchrotron via control of said radio-frequency generator,

wherein intensity comprises a number of the charged particles extracted as a function of time.

17. The apparatus of claim 15, further comprising:

at least three separate foils axially crossing a path of said charged particle raster beam, a first of said three foils housed in a tandem accelerator of an injector, a second of said three foils proximate a ring accelerator path of a synchrotron located along the path after said injector and prior to a beam transport system, and a third of said three foils positioned in said beam transport system.

18. The apparatus of claim 17, wherein said synchrotron comprises:

at least four turning sections;

bending magnets; and

focusing geometry, wherein each of said four turning sections comprises at least four of said bending magnets, wherein each of said bending magnets comprises said focusing geometry, wherein said focusing geometry narrows a metal section of said bending magnet from a first magnet cross-section to a second magnet cross-section, wherein said first magnet cross-section lies in a parallel plane to said second magnet cross-section, wherein said second magnet cross-section comprises a surface of a gap, wherein said gap comprises a surface of the path of the charged particle raster beam.

19. The apparatus of claim 17, wherein said synchrotron further comprises:

a beam intensity controller configured to both vary and control flux of the raster beam, said beam intensity controller electrically connected to an extraction foil, said extraction foil consisting essentially of atoms having six or fewer protons per atom.

20. The apparatus of claim 15, further comprising:

a negative ion source configured to produce negative ions in a negative ion beam path;

an ion beam focusing lens, comprising;

a first focusing electrode circumferentially surrounding the negative ion beam path;

a second focusing electrode comprising metal conductive paths at least partially blocking the negative ion beam path;

wherein first electric field lines run between said first focusing electrode and said second focusing electrode,

wherein the negative ions encounter first force vectors running up the first electric field lines that focus the negative ions,

a converting foil, said converting foil configured to convert the negative ions into the charged particle raster beam.