Method and device for cardiac vasoactive therapy
First Claim
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1. A cardiac device, comprising:
- a pulse generator for outputting vasoactive stimulation pulses, wherein the pulse generator is connectable to a vasoactive stimulation electrode disposed in proximity to a coronary artery;
a sensing amplifier for sensing cardiac electrical activity;
an impedance sensor for measuring cardiac blood flow;
a controller programmed to intermittently switch between a normal mode in which no vasoactive stimulation pulses are delivered or a vasodilation mode in which vasoactive stimulation pulses are delivered in a manner that causes vasodilation of the coronary artery; and
,wherein the controller is further programmed to deliver vasoactive stimulation pulses in the vasodilation mode such that the delivery of vasoactive stimulation pulses is timed to occur coincidentally with mechanical ventricular diastole as determined from the measured cardiac blood flow.
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Abstract
A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
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Citations
22 Claims
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1. A cardiac device, comprising:
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a pulse generator for outputting vasoactive stimulation pulses, wherein the pulse generator is connectable to a vasoactive stimulation electrode disposed in proximity to a coronary artery; a sensing amplifier for sensing cardiac electrical activity; an impedance sensor for measuring cardiac blood flow; a controller programmed to intermittently switch between a normal mode in which no vasoactive stimulation pulses are delivered or a vasodilation mode in which vasoactive stimulation pulses are delivered in a manner that causes vasodilation of the coronary artery; and
,wherein the controller is further programmed to deliver vasoactive stimulation pulses in the vasodilation mode such that the delivery of vasoactive stimulation pulses is timed to occur coincidentally with mechanical ventricular diastole as determined from the measured cardiac blood flow. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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implanting a pulse generator and an impedance sensor for measuring cardiac blood flow in a patient; implanting a vasoactive stimulation electrode connected to the pulse generator near a coronary artery and delivering vasoactive stimulation pulses to the coronary artery; programming the pulse generator to intermittently switch between a normal mode in which no vasoactive stimulation pulses are delivered or a vasodilation mode in which vasoactive stimulation pulses are delivered in a manner that causes vasodilation of the coronary artery; and
,further programming the pulse generator such that the delivery of vasoactive stimulation pulses in the vasodilation mode is timed to occur coincidentally with mechanical ventricular diastole as determined from the measured cardiac blood flow. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification