Integrating device-based sensors and bedside biomarker assays to detect worsening heart failure
First Claim
1. An apparatus comprising:
- two or more ambulatory physiological sensors configured to provide, to a user or automated process, a first heart failure status indicator using a first sensor selected from the two or more ambulatory physiological sensors and a second heart failure status indicator using a second sensor selected from the two or more ambulatory physiological sensors, the second sensor different from the first sensor;
an external biomarker sensor, configured to provide information to the user or automated process about an amount of a biomarker present in a biological substance, wherein the amount of the biomarker present provides information about heart failure status; and
a processor circuit, communicatively coupled to the at least one ambulatory physiological sensor and the external biomarker sensor, the processor configured to switch, in response to information from the biomarker sensor, from a first heart failure status detection mode detecting heart failure status using the first heart failure status indicator to a second heart failure status detection mode detecting heart failure status using a change over time in the second heart failure status indicator, the second heart failure status detection mode different from and having a higher specificity than the first heart failure status detection mode.
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Abstract
Devices and methods for improving the sensitivity and specificity of heart failure (HF) detection are described. The devices and methods can detect a HF status such as using physiological sensor data and external biomarker assays. An apparatus can comprise ambulatory physiological sensors that can provide a first HF status indicator and a second HF status indicator to a user. An external biomarker sensor can provide an amount of a biomarker present, such as an assay for B-type natriuretic peptide (BNP), which provides information about HF status. A processor circuit can switch from a first HF detection mode to a second detection mode such as in response to the information from the biomarker sensor. The first detection mode can detect HF status using the first HF status indicator, and the second detection mode can detect HF status using the second HF status indicator. The second detection mode can have a higher specificity than the first detection mode.
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Citations
20 Claims
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1. An apparatus comprising:
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two or more ambulatory physiological sensors configured to provide, to a user or automated process, a first heart failure status indicator using a first sensor selected from the two or more ambulatory physiological sensors and a second heart failure status indicator using a second sensor selected from the two or more ambulatory physiological sensors, the second sensor different from the first sensor; an external biomarker sensor, configured to provide information to the user or automated process about an amount of a biomarker present in a biological substance, wherein the amount of the biomarker present provides information about heart failure status; and a processor circuit, communicatively coupled to the at least one ambulatory physiological sensor and the external biomarker sensor, the processor configured to switch, in response to information from the biomarker sensor, from a first heart failure status detection mode detecting heart failure status using the first heart failure status indicator to a second heart failure status detection mode detecting heart failure status using a change over time in the second heart failure status indicator, the second heart failure status detection mode different from and having a higher specificity than the first heart failure status detection mode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method comprising:
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using at least one two or more ambulatory physiological sensors for providing a first heart failure status indicator using a first sensor selected from the two or more ambulatory physiological sensors and a second heart failure status indicator using a second sensor selected from the two or more ambulatory physiological sensors, the second sensor different from the first sensor; using an external biomarker sensor, detecting an amount of a biomarker present in a biological substance to provide information about heart failure status; using information about the amount of biomarker present, switching from a first heart failure status detection mode detecting heart failure status using the first heart failure status indicator to a second heart failure status detection mode detecting heart failure status using a change over time in the second heart failure status indicator, the second heart failure status detection mode different from and having a higher specificity than the first heart failure status detection mode. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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20. A non-transitory device-readable medium including instructions that, when performed by a device, comprise:
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using two or more ambulatory physiological sensors for providing a first heart failure status indicator using a first sensor selected from the two or more ambulatory physiological sensors and a second heart failure status indicator using a second sensor selected from the two or more ambulatory physiological sensors, the second sensor different from the first sensor; using an external biomarker sensor, detecting an amount of a biomarker present in a biological substance to provide information about heart failure status; and using information about the amount of biomarker present, switching from a first heart failure status detection mode detecting heart failure status using the first heart failure status indicator to a second heart failure status detection mode detecting heart failure status using a change over time in the second heart failure status indicator, the second heart failure status detection mode different from and having a higher specificity than the first heart failure status detection mode.
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Specification