Catheters with high-purity fluoropolymer additives

• US 8,603,070 B1
• Filed: 07/25/2013
• Issued: 12/10/2013
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc., Evonik Canada Inc. (Rag-Stiftung)
• Original Assignee: AngioDynamics, Inc.
• Inventors: Lareau, Raymond, Bell, Benjamin, Santerre, J. Paul, Ho, Jeannette
• Primary Examiner(s): SZEKELY, PETER A
• Application Number:
  US13/950,592
• Time in Patent Office: 138 Days
• Field of Search: 604/523, 604/529, 524/423
• US Class Current: 604/529
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61L 29/041 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/049 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 33/064 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: A61M 25/0021 characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: C08L 27/12 containing fluorine atoms
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.

Claims

1. A catheter comprising:

an elongated tubular structure comprising a first polymer comprising polyurethane and a second polymer comprising polyfluoro-oligomeric groups;

wherein said second polymer is characterized by a polystyrene equivalent weight average molecular weight (M_w) greater than 13 kDa.

2. The catheter of claim 1, wherein said second polymer has a polydispersity index of between 1.0 and 2.0.

3. The catheter of claim 2, wherein said second polymer has a polydispersity index of between 1.0 and 1.5.

4. The catheter of claim 1, wherein said second polymer is characterized by a polystyrene equivalent weight average molecular weight (M_w) within the range of 14 kDa to 26 kDa.

5. The catheter of claim 1, wherein said polyurethane comprises a polycarbonate-based polyurethane.

6. The catheter of claim 1, wherein said elongated tubular structure further comprises a radiopaque material.

7. The catheter of claim 6, wherein said elongated tubular structure comprises about 25 weight percent to about 35 weight percent of said radiopaque material.

8. The catheter of claim 7, wherein said elongated tubular structure comprises about 1.5 weight percent to about 2.5 weight percent of said second polymer.

9. The catheter of claim 6, wherein said radiopaque material comprises barium sulfate.

10. The catheter of claim 9, wherein said elongated tubular structure comprises up to about 30 weight percent of said barium sulfate.

11. The catheter of claim 1, wherein said elongated tubular structure comprises an outer surface, at least one lumen, and a wall thickness between said outer surface and said at least one lumen, said wall thickness being at least 0.005 inches.

12. The catheter of claim 1, wherein said elongated tubular structure comprises an outer surface, at least two lumens, and a wall thickness between said outer surface and any of said at least two lumens, said wall thickness being at least 0.005 inches.

13. The catheter of claim 1, wherein said elongated tubular structure comprises an outer surface, at least three lumens, and a wall thickness between said outer surface and any of said at least three lumens, said wall thickness being at least 0.005 inches.

14. A catheter comprising:

an elongated tubular structure comprising a polymeric material comprising;

a first polymer comprising polyurethane; and

additives comprising a second polymer comprising polyfluoro-oligomeric groups;

wherein said second polymer is characterized by a polystyrene equivalent weight average molecular weight (M_w) greater than 13 kDa and a polydispersity index of between 1.0 and 2.0.

15. The catheter of claim 14, wherein said polymeric material comprises up to about 44 weight percent of said additives.

16. The catheter of claim 14, wherein said polymeric material comprises up to about 40 weight percent of said additives.

17. The catheter of claim 14, wherein said polymeric material comprises up to about 33 weight percent of said additives.

18. The catheter of claim 14, wherein said polymeric material comprises about 25 weight percent to about 35 weight percent of a radiopaque material.

19. The catheter of claim 18, wherein said polymeric material comprises about 1.5 weight percent to about 2.5 weight percent of said second polymer.

20. The catheter of claim 19, wherein said polymeric material comprises up to about 0.2 weight percent of a colorant.