Methods and systems for treating restenosis using electroporation
First Claim
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1. A method for reducing restenosis by irreversible electroporation, comprising:
- introducing a balloon with a plurality of electrodes through vasculature to a restenosis site;
positioning the balloon at or near the restenosis site;
delivering a test voltage to cells in the restenosis site prior to applying a programmed electric field to the restenosis siteusing a programmed control circuit, applying a programmed electric field to the restenosis site among the electrodes through a switching device to activate the electrodes in a selected pattern among a plurality of switching patterns in an amount which is sufficient to induce irreversible electroporation of the restenosis site, but which is insufficient to induce thermal damage to the restenosis site such that the cells in the restenosis site are ablated by irreversible electroporation.
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Abstract
A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.
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Citations
38 Claims
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1. A method for reducing restenosis by irreversible electroporation, comprising:
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introducing a balloon with a plurality of electrodes through vasculature to a restenosis site; positioning the balloon at or near the restenosis site; delivering a test voltage to cells in the restenosis site prior to applying a programmed electric field to the restenosis site using a programmed control circuit, applying a programmed electric field to the restenosis site among the electrodes through a switching device to activate the electrodes in a selected pattern among a plurality of switching patterns in an amount which is sufficient to induce irreversible electroporation of the restenosis site, but which is insufficient to induce thermal damage to the restenosis site such that the cells in the restenosis site are ablated by irreversible electroporation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for reducing restenosis by electroporation, comprising:
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introducing a balloon with a plurality of electrodes through vasculature to a restenosis site; positioning the balloon and the electrodes at or near the restenosis site; receiving through a user interface a selection of a desired switching pattern among a plurality of switching patterns from a user; delivering a test voltage to cells in the restenosis site; after delivering the test voltage, using a programmed control circuit, applying a programmed plurality of electrical pulses to the restenosis site among the electrodes through a switching device to activate the electrodes in the user-selected pattern in an amount which is sufficient to induce electroporation of the restenosis site. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38)
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Specification