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Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction

  • US 8,603,462 B2
  • Filed: 03/31/2004
  • Issued: 12/10/2013
  • Est. Priority Date: 04/01/2003
  • Status: Expired due to Fees
First Claim
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1. A method of treating acute renal failure, comprising delivering a single biologically and physiologically compatible solution containing a therapeutic amount of isolated human mesenchymal stem cells to a patient in need thereof, wherein the solution is not enriched for human pluripotent hematopoietic stem cells, wherein the therapeutic amount of human mesenchymal stem cells is between about 0.01 to about 5×

  • 106 mesenchymal stem cells per kilogram of patient weight, wherein the human mesenchymal stem cells are not co-administered with hematopoietic stem cells, wherein the patient suffers from or is at high risk of suffering from an acute deterioration in renal excretory function and wherein the mesenchymal stem cells are expanded in vitro to produce an enriched population of mesenchymal stem cells.

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