Compositions and methods for biological remodeling with frozen particle compositions

• US 8,603,495 B2
• Filed: 03/31/2009
• Issued: 12/10/2013
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): Rider, Lance W
• Application Number:
  US12/384,201
• Publication Number:
  US 20100111938A1
• Time in Patent Office: 1,715 Days
• Field of Search: None
• US Class Current: 424/400
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C07K 16/2824 against CD58
• CPC Class Codes: C07K 16/283 against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 from tumour cells

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen particle composition, comprising:

one or more frozen particles coated with at least one neuro-muscular toxin and further include at least one biological remodeling agent including collagen and one or more of vitamin A, vitamin C, fibrin, thrombin, hyaluronic acid, hydroxylapatite, keratin, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, cellulose, polyaldehyde glucornate, Factor XIII, Factor XII, silicone, polyurethane, elastin, glycosaminoglycan, poly(alpha-hydroxyacid), or glutaraldehyde;

wherein the one or more frozen particles have at least one major dimension of approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

2. The frozen particle composition of claim 1, wherein the at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter.

3. The frozen particle composition of claim 1, further including one or more extracellular matrix components.

4. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is located in at least one cavity of the frozen particle compositions.

5. The frozen particle composition of claim 1, further including one or more of a blood cell, chondrocyte, endothelial cell, hepatocyte, keratinocyte, myocyte, osteoblast, osteoclast, osteocyte, mesenchymal cell, stem cell, progenitor cell, or fibroblast.

6. The frozen particle composition of claim 1, wherein the collagen includes one or more of Type I collagen, Type II collagen, Type III collagen, Type VII collagen, Type X collagen, elastin fibers, or soluble elastin.

7. The frozen particle composition of claim 1, wherein the biological remodeling agent includes one or more of an angiogenic factor, growth factor, or cytokine.

8. The frozen particle composition of claim 1, further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

9. The frozen particle composition of claim 1, the frozen particles further including at least one antimicrobial agent.

10. The frozen particle composition of claim 9, wherein the at least one antimicrobial agent includes at least one antibiotic or anti-fungal agent.

11. The frozen particle composition of claim 9, wherein the at least one antimicrobial agent includes one or more of penicillin, cephalosporin, polymixin, sulfonamide, beta-lactam antibiotic, beta-lactamase inhibitor, enediynes, lincosamide antibiotic, nitroimidazole antibiotic, pleuromutilin antibiotic, polyketide antibiotic, polymyxin antibiotic, polypeptide antibiotic, antimicrobial peptides, quinolone antibiotic, rifamycin antibiotic, sulfonamide antibiotic, tetracycline antibiotic, aminoglycoside antibiotic, macrolide, tetracycline, cyclic lipopeptide, glycylcycline, oxazolidinone, amoxicillin, tobramycin, levofloxacin, gatifloxacin, moxifloxacin, streptomycin, oxytetracycline, chloramphenicol, or ampicillin.

12. The frozen particle composition of claim 1, further including at least one cytotixic agent.