Nanoshell therapy

• US 8,603,530 B2
• Filed: 06/14/2006
• Issued: 12/10/2013
• Est. Priority Date: 06/14/2006
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Ludwig, Florian N.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): SAMALA, JAGADISHWAR RAO
• Application Number:
  US11/453,704
• Publication Number:
  US 20070292518A1
• Time in Patent Office: 2,736 Days
• Field of Search: 424/422, 424/489, 424/490, 424/497, 424/423, 424/9.24, 424/178.1, 424/403, 424/617, 428/292.1, 428/403, 428/407, 428/40, 604/523, 604 96-103, 604/264, 604/265, 600/37, 606/2, 606 4- 9, 606/27, 606/151, 523/54.2, 523/112, 514/12, 525/333.3
• US Class Current: 424/489
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61N 5/00 Radiation therapy ultrasound therapy A61N7/00; devices or apparatus applicable to both therapy and diagnosis A61B6/00
• CPC Class Codes: Y10T 428/249924 Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
• CPC Class Codes: Y10T 428/2991 Coated

Abstract

Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a vascular condition are provided.

Claims

1. A medical device for treating or ameliorating a vascular condition, comprising:

(a) nano-constructs that comprise a core material and a carbon or conducting polymer nanoshell formed on the core material, said carbon or conducting polymer nanoshell having a thickness between about 2 nm to about 100 nm and

(b) delivery means for delivering the nano-constructs to a target tissue of a subject;

wherein the nano-constructs are capable of absorbing an energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat, and wherein the nano-constructs comprise targeting molecules on a surface of the nano-constructs, and the targeting molecules are selected from the group consisting of YIGSR, peptides and antibodies to IIbIIIa, hyaluronic acid, ICAM-1, ICAM-2, ICAM-3, thrombospondin osteopontin, N-CAM, PECAM-1, IgCAM, oligonucleotide aptamers, selectins, cadherins, and combinations thereof.

2. The medical device of claim 1, wherein the delivery means is a vascular stent.

3. The medical device of claim 2, wherein the nano-constructs are embedded within a polymer coating on at least a portion of the stent.

4. The medical device of claim 2, wherein the stent comprises a porous structure or micro depots on a surface, and wherein the nano-constructs are placed in the porous structure or the micro depots.

5. A system for treating or ameliorating a vascular condition comprising:

a medical device of claim 1 for treating or ameliorating a vascular condition; and

an energy source to apply energy.

6. The system of claim 5, wherein the energy source is capable of applying near infrared (NIR) electromagnetic radiation.

7. The system of claim 5, wherein the targeting molecules on the surface of the nano-constructs of the medical device are YIGSR, antibodies to IIbIIIa, ICAM-1, ICAM-2, ICAM-3, thrombospondin, osteopontin, N-CAM, PECAM-1, IgCAM, oligonucleotide aptamers, selectins, and combinations thereof.

8. The system of claim 5 wherein said nano-constructs comprise conducting polymer nanoshells having a thickness between about 2 nm to about 100 nm and said conducting polymer is selected from the group consisting of poly(pyrrole), poly(thiophene), poly(acetylene), poly(aniline), graphite, carbon nanotubes, DNA, and combinations thereof.

9. The system of claim 5 wherein said core material is non-conducting and selected from the group consisting of silicon oxide, silica, aluminum oxide, biopolymers, polymers, and combinations thereof.

10. The medical device of claim 1, wherein the nano-constructs comprise a surface-stealthing compound on the surface of the nano-constructs such that the circulation time of the nano-constructs is increased.

11. The medical device of claim 10, wherein the surface-stealthing compound is poly(ethylene glycol).

12. The medical device of claim 1, wherein the targeting molecules on the surface of the nano-constructs are selected from the group consisting of YIGSR, antibodies to IIbIIIa, ICAM-1, ICAM-2, ICAM-3, thrombospondin, osteopontin, N-CAM, PECAM-1, IgCAM, oligonucleotide aptamers, selectins;

and combinations thereof.

13. The medical device of claim 1, wherein the means of delivery comprises a catheter.

14. The medical device of claim 1, wherein the targeting molecules are attached on the surface of the nano-constructs by a spacer.

15. The medical device of claim 14, wherein the spacer is selected from the group consisting of a C₁-C₂₀ alkyl, a C₃-C₂₀ cycloalkyl, poly(ethylene glycol), poly(alkylene oxide) and any combination thereof.

16. The medical device of claim 15, wherein the spacer is selected from the group consisting of a C₁-C₂₀ alkyl, a C₃-C₂₀ cycloalkyl, and any combination thereof.

17. The medical device of claim 14, wherein the spacer is selected from the group consisting of dextran, dextrose, heparin, poly(propylene sulfide), hyaluronic acid, PVA, PVP, and any combination thereof.

18. The medical device of claim 1, wherein the delivery means comprises a catheter-based device selected from the group consisting of a single needle injection catheter, a dual needle injection catheter, a porous balloon catheter, a balloon catheter with jets, and a double balloon catheter.

19. The medical device of claim 1 wherein said nano-constructs comprise conducting polymer nanoshells having a thickness between about 2 nm to about 100 nm and said conducting polymer is selected from the group consisting of poly(pyrrole), poly(thiophene), poly(acetylene), poly(aniline), graphite, carbon nanotubes, DNA, and combinations thereof.

20. The medical device of claim 1 wherein said core material is non-conducting and selected from the group consisting of silicon oxide, silica, aluminum oxide, biopolymers, polymers, and combinations thereof.

21. A medical device for treating or ameliorating a vascular condition, comprising:

(a) nano-constructs that comprise a core material and a carbon or conducting polymer nanoshell formed on the core material, said carbon or conducting polymer nanoshell having a thickness between about 2 nm to about 100 nm, and

(b) delivery means for delivering the nano-constructs to a target tissue of a subject;

wherein the nano-constructs are capable of absorbing an energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat;

wherein the nano-constructs comprise targeting molecules attached on a surface of the nano-constructs by a C₃-C₂₀ cycloalkyl spacer; and

wherein the targeting molecules are surface-conjugated ligands against receptors on an inflamed endothelium.

22. The medical device of claim 21 wherein said nano-constructs comprise conducting polymer nanoshells having a thickness between about 2 nm to about 100 nm and said conducting polymer is selected from the group consisting of poly(pyrrole), poly(thiophene), poly(acetylene), poly(aniline), graphite, carbon nanotubes, DNA, and combinations thereof.

23. The medical device of claim 21 wherein said core material is non-conducting and selected from the group consisting of silicon oxide, silica, aluminum oxide, biopolymers, polymers, and combinations thereof.