Nanoshell therapy
First Claim
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1. A medical device for treating or ameliorating a vascular condition, comprising:
- (a) nano-constructs that comprise a core material and a carbon or conducting polymer nanoshell formed on the core material, said carbon or conducting polymer nanoshell having a thickness between about 2 nm to about 100 nm and(b) delivery means for delivering the nano-constructs to a target tissue of a subject;
wherein the nano-constructs are capable of absorbing an energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat, and wherein the nano-constructs comprise targeting molecules on a surface of the nano-constructs, and the targeting molecules are selected from the group consisting of YIGSR, peptides and antibodies to IIbIIIa, hyaluronic acid, ICAM-1, ICAM-2, ICAM-3, thrombospondin osteopontin, N-CAM, PECAM-1, IgCAM, oligonucleotide aptamers, selectins, cadherins, and combinations thereof.
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Abstract
Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a vascular condition are provided.
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Citations
23 Claims
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1. A medical device for treating or ameliorating a vascular condition, comprising:
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(a) nano-constructs that comprise a core material and a carbon or conducting polymer nanoshell formed on the core material, said carbon or conducting polymer nanoshell having a thickness between about 2 nm to about 100 nm and (b) delivery means for delivering the nano-constructs to a target tissue of a subject; wherein the nano-constructs are capable of absorbing an energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat, and wherein the nano-constructs comprise targeting molecules on a surface of the nano-constructs, and the targeting molecules are selected from the group consisting of YIGSR, peptides and antibodies to IIbIIIa, hyaluronic acid, ICAM-1, ICAM-2, ICAM-3, thrombospondin osteopontin, N-CAM, PECAM-1, IgCAM, oligonucleotide aptamers, selectins, cadherins, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A medical device for treating or ameliorating a vascular condition, comprising:
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(a) nano-constructs that comprise a core material and a carbon or conducting polymer nanoshell formed on the core material, said carbon or conducting polymer nanoshell having a thickness between about 2 nm to about 100 nm, and (b) delivery means for delivering the nano-constructs to a target tissue of a subject; wherein the nano-constructs are capable of absorbing an energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat; wherein the nano-constructs comprise targeting molecules attached on a surface of the nano-constructs by a C3-C20 cycloalkyl spacer; and wherein the targeting molecules are surface-conjugated ligands against receptors on an inflamed endothelium. - View Dependent Claims (22, 23)
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Specification