Compositions for topical treatment

• US 8,603,550 B1
• Filed: 05/15/2013
• Issued: 12/10/2013
• Est. Priority Date: 05/15/2013
• Status: Active Grant

• Current Assignee: Normajean Fusco
• Original Assignee: Normajean Fusco
• Inventors: Fusco, Normajean
• Primary Examiner(s): MELLER, MICHAEL V
• Application Number:
  US13/895,354
• Time in Patent Office: 209 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/463 containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• CPC Class Codes: A61K 8/84 : obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/891 : saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 : Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations

Abstract

A stable, self-preserving, antimicrobial, composition suitable for the treatment of a variety of dermal as well as subcutaneous conditions. The compositions include as an active ingredient a quaternary ammonium compound, preferably benzethonium chloride, potentiated and synergized with menthyl lactate cooling agent in a cationic carrier. Optionally, a phenoxyethanol preservative and chlorhexidine digluconate antibacterial agent may be used to assist in enhancing the activity. The compositions kill a broad spectrum of gram-negative and gram-positive bacteria, fungus and yeasts. The compositions are used as first aid skin treatments and as skin sanitizers to help prevent bacterial contamination of minor cuts, scrapes and burns. The compositions are particularly useful when applied to the skin after hair removal in that they additionally cool, soothe and moisturize the skin. The compositions may also serve as a base vehicle in which additional skin care ingredients may be added to provide additional functionality to the compositions.

Claims

1. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to said skin of the human, a therapeutically effective amount of a composition of a quaternary ammonium polymer, benzethonium chloride, stearic acid, 2-octyldodecanol, behentrimonium methosulfate, linear polydimethylsiloxane fluid, cetyl alcohol, menthyl lactate, phenoxyethanol, chamomile extract, witch hazel extract, bisabalol and chlorhexidine gluconate.

2. The method of treating bacterial contamination of claim 1, wherein the quaternary ammonium polymer in the composition is present in an amount of between 0.1 to 10.0% by weight.

3. The method of treating bacterial contamination of claim 1, wherein the benzethonium chloride in the composition is present in an amount of between 0.1 to 0.2% by weight.

4. The method of treating bacterial contamination of claim 1, wherein the stearic acid polymer in the composition is present in an amount of between 0.1-1.0% by weight.

5. The method of treating bacterial contamination of claim 1, wherein the 2-octyldodecanol in the composition is present in an amount of between 0.1-3.0% by weight.

6. The method of treating bacterial contamination of claim 1, wherein the behentrimonium methosulfate in the composition is present in an amount of between 0.1 to 10.0% by weight.

7. The method of treating bacterial contamination of claim 1, wherein the linear polydimethylsiloxane fluid in the composition is present in an amount of between 0.1-10% by weight.

8. The method of treating bacterial contamination of claim 1, wherein the cetyl alcohol in the composition is present in an amount of between 0.5-3.0% % by weight.

9. The method of treating bacterial contamination of claim 1, wherein the menthyl lactate in the composition is present in an amount of between 0.1 to 10.0% by weight.

10. The method of treating bacterial contamination of claim 1, wherein the phenoxyethanol in the composition is present in an amount of between 0.1-2.0% by weight.

11. The method of treating bacterial contamination of claim 1, wherein the chamomile extract in the composition is present in an amount of between 0.1-5.0% by weight.

12. The method of treating bacterial contamination of claim 1, wherein the witch hazel extract in the composition is present in an amount of between 0.1-5.0% by weight.

13. The method of treating bacterial contamination of claim 1, wherein the bisabalol in the composition is present in an amount of between 0.1-1.0% by weight.

14. The method of treating bacterial contamination of claim 1, wherein the chlorhexidine in the composition is present in an amount of between 0.001-1.0% by weight.

15. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to said skin of the human, a therapeutically effective amount of a composition by weight percent of