Methods and systems for monitoring bioactive agent use

• US 8,606,592 B2
• Filed: 07/07/2008
• Issued: 12/10/2013
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Harvest Bio LLC
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Sweeney, Elizabeth A., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): NGUYEN, HIEP VAN
• Application Number:
  US12/217,620
• Publication Number:
  US 20090271120A1
• Time in Patent Office: 1,982 Days
• Field of Search: 705/2
• US Class Current: 705/2
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage
• CPC Class Codes: G16H 70/60 relating to pathologies

Abstract

Methods, computer program products, and systems are described that include accepting at least one indication of a bioactive agent use by an individual and/or assigning an artificial sensory experience to monitor at least one desired effect of the bioactive agent on the individual.

Claims

1. A system, comprising:

an acceptor module configured to accept at least one indication of bioactive agent use by an individual;

an assigner module configured to assign a virtual world to monitor at least one response time of the individual;

an effect predictor module configured to predict at least one response time of the individual in the virtual world based at least in part on the indicated bioactive agent accepted by the acceptor module; and

a reporter module configured to report the at least one response time predicted by the effect predictor module and at least one monitored response time in the virtual world assigned by the assigner module,

wherein at least one of the acceptor module, the assigner module, the effect predictor module or the reporter module is at least partially implemented in computing hardware.

2. The system of claim 1, wherein the acceptor module configured to accept at least one indication of bioactive agent use by an individual comprises:

a bioactive agent identification acceptor module configured to accept an identification of at least one bioactive agent prescribed for the individual.

3. The system of claim 1, wherein the acceptor module configured to accept at least one indication of bioactive agent use by an individual comprises:

a substance abuse indication acceptor module configured to accept an indication of a substance subject to abuse used by the individual.

4. The system of claim 1, wherein the acceptor module configured to accept at least one indication of bioactive agent use by an individual comprises:

a nutraceutical identification acceptor module configured to accept an indication of nutraceutical use by the individual.

5. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a sensate experience assigner module configured to assign a sensate experience.

6. The system of claim 5, wherein the sensate experience assigner module configured to assign a sensate experience comprises:

a stimulus assessor module configured to assess at least one reaction to at least one of an olfactory stimulus, a haptic stimulus, a visual stimulus, an auditory stimulus, or a taste stimulus.

7. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

an automated medical device receiver module configured to receive data from an automated medical device.

8. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

an assigner module configured to assign at least one of a virtual world, a modification to a virtual world, a computer game, a modification to a computer game, a website, a modification to a website, an online course, or a modification to an online course.

9. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a monitorer module configured to monitor at least one of physical activity, body weight, body mass index, heart rate, blood oxygen level, or blood pressure temporally associated with an artificial sensory experience.

10. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a neurophysiological measurement monitorer module configured to monitor a neurophysiological measurement.

11. The system of claim 10, wherein the neurophysiological measurement monitorer module configured to monitor a neurophysiological measurement comprises:

a physiologic activity measurer module configured to measure at least one physiologic activity using at least one of electroencephalography, computed axial tomography, positron emission tomography, magnetic resonance imaging, functional magnetic resonance imaging, functional near-infrared imaging, or magnetoencephalography.

12. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a brain activity surrogate marker measurer module configured to measure at least one brain activity surrogate marker.

13. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a near real time measurer module configured to assign an artificial sensory experience to measure at least one effect of the bioactive agent in at least one of near real time or real time.

14. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

a test function output measurer module configured to measure at least one of visual field test function output, eye movement test function output, pupil movement test function output, face pattern test function output, hearing test function output, or voice test function output.

15. The system of claim 1, wherein the assigner module configured to assign a virtual world to monitor at least one response time of the individual comprises:

an effect recorder module configured to record at least one monitored effect of the bioactive agent.

16. The system of claim 1, further comprising:

an effect reporter module configured to report at least one monitored effect.

17. The system of claim 16, wherein the effect reporter module configured to report at least one monitored effect comprises:

a third party reporter module configured to report to at least one third party.

18. The system of claim 16, wherein the effect reporter module configured to report at least one monitored effect comprises:

a compliance data reporter module configured to report at least some compliance data.

19. The system of claim 16, wherein the effect reporter module configured to report at least one monitored effect comprises:

a selective reporter module configured to selectively report at least one monitored effect.

20. The system of claim 1, further comprising:

a predictor module configured to predict at least one effect of the bioactive agent.

21. The system of claim 20, wherein the predictor module configured to predict at least one effect of the bioactive agent comprises:

an effect predictor module configured to predict at least one effect of the virtual world on at least one efficacy of the bioactive agent.

22. The system of claim 20, wherein the predictor module configured to predict at least one effect of the bioactive agent comprises:

a behavioral response predictor module configured to predict at least one behavioral response.

23. The system of claim 1, wherein the acceptor module configured to accept at least one indication of bioactive agent use by an individual comprises:

an acceptor module configured to accept at least one indication of an effect associated with a bioactive agent.

24. The system of claim 1, wherein the effect predictor module configured to predict at least one response time of the individual in the virtual world based at least in part on the indicated bioactive agent accepted by the acceptor module comprises:

an effect predictor module associated with at least one of a mathematical model, prediction software, an algorithm, or a statistical model.

25. The system of claim 1, wherein the effect predictor module configured to predict at least one response time of the individual in the virtual world based at least in part on the indicated bioactive agent accepted by the acceptor module comprises:

an effect predictor module configured to utilize empirical data and compare the empirical data with characteristics of the individual.

26. The system of claim 1, wherein the effect predictor module configured to predict at least one response time of the individual in the virtual world based at least in part on the indicated bioactive agent accepted by the acceptor module comprises:

an effect predictor module associated with at least one of trend estimation, regression analysis, or data extrapolation.