Systems and devices for generating nitric oxide

• US 8,607,785 B2
• Filed: 08/13/2009
• Issued: 12/17/2013
• Est. Priority Date: 08/21/2008
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Fine, David H., Johnson, Bryan, Vasquez, Gregory
• Primary Examiner(s): Yu, Justine R
• Assistant Examiner(s): Stuart, Colin W
• Application Number:
  US12/541,137
• Publication Number:
  US 20100043787A1
• Time in Patent Office: 1,587 Days
• Field of Search: 128/202.26, 128/200.24, 128/203.12, 128/203.22, 128/204.14, 128/204.18, 422/129, 423/402
• US Class Current: 128/202.26
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/109 the humidifying liquid or the beneficial agent
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A62B 21/00 Devices for producing oxygen from chemical substances for respiratory apparatus
• CPC Class Codes: A62B 7/08 containing chemicals producing oxygen
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Claims

1. A device for generating nitric oxide from nitrogen dioxide, comprising:

a body including an inlet, an outlet and a diverter; and

a porous solid matrix positioned within the body and a space between the body and the porous solid matrix, wherein the porous solid matrix includes a thermoplastic resin and silica gel, wherein the porous solid matrix is coated with an antioxidant, and wherein the inlet is configured to receive a gas flow, the diverter directs the gas flow to the space between the body and the porous solid matrix, and the gas flow is fluidly communicated to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide.

2. The device of claim 1, further comprising a humidifier in communication with the inlet of the body.

3. The device of claim 1, wherein the antioxidant is ascorbic acid, alpha tocopherol, or gamma tocopherol.

4. The device of claim 1, wherein the density of the silica gel is similar to the density of the thermoplastic resin.

5. The device of claim 1, wherein the porous solid matrix comprises at least 20% silica gel.

6. The device of claim 1, wherein the porous solid matrix comprises approximately 20% to approximately 60% silica gel.

13. The device of claim 1, wherein the space is between the inlet and the porous solid matrix.

7. A system for delivering nitric oxide to a patient, comprising:

a gas source of nitrogen dioxide, dinitrogen tetraoxide, or nitric oxide;

a first device having a body including an inlet, an outlet, a diverter, a porous solid matrix including a thermoplastic resin and silica gel and a space between the body and the porous solid matrix, wherein the porous solid matrix is coated with an antioxidant and the porous solid matrix is positioned between the inlet and the outlet, wherein the inlet is configured to receive a gas flow from the source, the diverter directs the gas flow to the space between the body and the porous solid matrix, and the gas flow is fluidly communicated to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide; and

a patient interface coupled to the outlet of the first device, the patient interface delivering nitric oxide to the patient.

8. The system of claim 7, further comprising a humidifier positioned between the gas source and the first device.

9. The system of claim 8, wherein the humidifier is integral with the first device.

10. The system of claim 7, further comprising a humidifier positioned prior to the patient interface.

11. The system of claim 8, further comprising:

a second humidifier positioned after the first device; and

a second device positioned after a second humidifier, the second device comprising an inlet, an outlet, and a porous solid matrix coated with an antioxidant, wherein the inlet is configured to receive a gas flow from the first device and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide.

12. The system of claim 7, wherein the antioxidant is ascorbic acid, alpha tocopherol, or gamma tocopherol.

14. The system of claim 7, wherein the space is between the inlet and the porous solid matrix.