Devices for delivering substances through an extra-anatomic opening created in an airway

• US 8,608,724 B2
• Filed: 11/04/2010
• Issued: 12/17/2013
• Est. Priority Date: 07/19/2004
• Status: Active Grant

• Current Assignee: Broncus Medical Incorporated
• Original Assignee: Broncus Medical Incorporated
• Inventors: Roschak, Edmund J.
• Primary Examiner(s): Mehta, Bhisma
• Application Number:
  US12/939,968
• Publication Number:
  US 20110146674A1
• Time in Patent Office: 1,139 Days
• Field of Search: 604/500, 604/506, 604/507, 604/508, 604/510
• US Class Current: 604/506
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61M 2025/1081 having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.

Claims

1. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:

advancing a catheter through a natural respiratory opening and into the lung;

advancing the catheter through the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall; and

treating the treatment site using the catheter.

2. The method of claim 1, wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.

3. The method of claim 2, wherein the step of delivering the substance through the existing artificially created opening comprises delivering the substance through the existing artificially created opening to treat a tumor.

4. The method of claim 2, wherein the substance comprises a substance selected from the group consisting of antimetabolites, antithrobotics, anticoagulants, antiplatelet agents, thorombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, agents that inhibit restenosis, anti-angiogenic agents or angiogenesis inhibitors, smooth muscle cell inhibitors, growth factors, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters and a combination thereof.

5. The method of claim 1, further comprising preventing closure of the existing artificially created opening wherein said preventing step is performed using a mechanical means.

6. The method of claim 5, wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant within and b) dilating the existing artificially created opening.

7. The method of claim 1, further comprising creating the existing artificially created opening.

8. The method of claim 1 wherein the catheter comprises a rounded distal end.

9. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:

advancing a catheter through a natural respiratory opening and into the lung;

advancing a rounded end of the catheter through the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall; and

treating the treatment site using the catheter.

10. The method of claim 9, wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.

11. The method of claim 10, wherein the step of delivering the substance through the existing artificially created opening comprises delivering the substance through the existing artificially created opening to treat a tumor.

12. The method of claim 10, further comprising creating the existing artificially created opening.

13. The method of claim 9, further comprising preventing closure of the existing artificially created opening wherein said preventing step is performed using a mechanical means.

14. The method of claim 13, wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant within and b) dilating the existing artificially created opening.

15. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:

advancing a catheter through a natural respiratory opening and into the lung;

creating an artificial opening through the airway wall with a piercing member;

enlarging the artificial opening;

advancing a rounded end of the catheter into the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall;

preventing closure of the artificially created opening; and

treating the treatment site using the catheter.

16. The method of claim 15, wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.

17. The method of claim 15, further comprising delivering electrical energy with the catheter.

18. The method of claim 15, wherein preventing closure of the artificially created opening is performed using a mechanical means.

19. The method of claim 18, wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant in the artificially created opening, b) dilating the artificially created opening, and c) temporarily holding open the artificially created opening with an instrument.

20. The method of claim 15, wherein said piercing member is withdrawn from the opening prior to advancing the rounded end of the catheter.