Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)

• US 8,609,026 B2
• Filed: 05/24/2012
• Issued: 12/17/2013
• Est. Priority Date: 01/28/2008
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Fine, David, Vasquez, Gregory, Rounbehler, David P.
• Primary Examiner(s): Jones, Christopher P
• Application Number:
  US13/480,376
• Publication Number:
  US 20120238031A1
• Time in Patent Office: 572 Days
• Field of Search: 422/120, 422/129, 422/177, 951/28, 951/29, 424/718, 128/203.12, 128/205.27, 73/232, 423/235, 423/239.1, 423/400, 423/405
• US Class Current: 422/120
• CPC Class Codes: A61D 7/04 Devices for anaesthetising animals by gases or vapours; Inhaling devices
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/009 Removing used or expired gases or anaesthetic vapours filtering, sterilising or disinfecting the exhaust air in drainage systems A61M1/784; bacterial filters in the expiratory path A61M16/1065
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence
• CPC Class Codes: C01B 21/32 Apparatus
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence
• CPC Class Codes: Y10T 436/179228 : Both nitrogen oxide and dioxide

Abstract

Various systems, devices, NO₂ absorbents, NO₂ scavengers and NO₂ recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

Claims

1. A method of sampling NO and NO₂ gas in a NO delivery system comprising

obtaining a sample of gas from the NO delivery system, wherein the gas includes nitric oxide and oxygen;

diluting the sample of gas no more than by 50% with air to reduce the concentration of nitric oxide and oxygen in the sample of gas; and

measuring the amount of NO and NO₂ gas in the sample with a gas analyzer.

2. The method of claim 1, wherein the sample of gas is diluted with air from a hospital room.

3. The method of claim 1, wherein the sample of gas is diluted with air from a wall.