Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)

• US 8,609,028 B2
• Filed: 07/23/2012
• Issued: 12/17/2013
• Est. Priority Date: 08/18/2004
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Rounbehler, David R., Fine, David H.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US13/555,567
• Publication Number:
  US 20130017277A1
• Time in Patent Office: 512 Days
• Field of Search: 422/120, 422/122, 423/235, 95/93, 951/02, 951/20, 128/200.14
• US Class Current: 422/120
• CPC Class Codes: A61D 7/04 Devices for anaesthetising animals by gases or vapours; Inhaling devices
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.

Claims

1. A method for delivering nitric oxide to a subject comprising:

introducing a nitric-oxide releasing agent into a receptacle including an inlet, an outlet and a porous support coated with a reducing agent, wherein the reducing agent is selected from a group consisting of ascorbic acid, alpha tocopherol or gamma tocopherol, and wherein the nitric-oxide releasing agent includes nitrogen dioxide;

converting the nitrogen dioxide in the nitric-oxide releasing agent to nitric oxide gas by contacting the nitrogen dioxide with the reducing agent; and

delivering the nitric oxide gas to the subject in a gas flow.

2. The method of claim 1, wherein the nitric-oxide releasing agent is nitrogen dioxide gas.

3. The method of claim 1, wherein the porous support comprises a substrate that retains water.

4. The method of claim 1, wherein the porous support is a porous hydrophilic polymer.

5. The method of claim 1, wherein the porous support comprises a silica gel.

6. A method for delivering nitric oxide to a subject comprising:

introducing a nitric-oxide releasing agent in an air flow into a receptacle including an inlet, an outlet and a porous support coated with a reducing agent, wherein the reducing agent is selected from a group consisting of ascorbic acid, alpha tocopherol or gamma tocopherol, and wherein the nitric-oxide releasing agent includes nitrogen dioxide;

converting the nitrogen dioxide in the nitric-oxide releasing agent to nitric oxide gas in the air flow by contacting the nitrogen dioxide with the reducing agent; and

delivering the nitric oxide gas to the subject in a gas flow including the air flow.

7. The method of claim 6, wherein the nitric-oxide releasing agent is nitrogen dioxide gas.

8. The method of claim 6, wherein the porous support comprises a substrate that retains water.

9. The method of claim 6, wherein the porous support is a porous hydrophilic polymer.

10. The method of claim 6, wherein the porous support comprises a silica gel.