Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)
First Claim
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1. A method for delivering nitric oxide to a subject comprising:
- introducing a nitric-oxide releasing agent into a receptacle including an inlet, an outlet and a porous support coated with a reducing agent, wherein the reducing agent is selected from a group consisting of ascorbic acid, alpha tocopherol or gamma tocopherol, and wherein the nitric-oxide releasing agent includes nitrogen dioxide;
converting the nitrogen dioxide in the nitric-oxide releasing agent to nitric oxide gas by contacting the nitrogen dioxide with the reducing agent; and
delivering the nitric oxide gas to the subject in a gas flow.
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Abstract
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
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Citations
10 Claims
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1. A method for delivering nitric oxide to a subject comprising:
introducing a nitric-oxide releasing agent into a receptacle including an inlet, an outlet and a porous support coated with a reducing agent, wherein the reducing agent is selected from a group consisting of ascorbic acid, alpha tocopherol or gamma tocopherol, and wherein the nitric-oxide releasing agent includes nitrogen dioxide; converting the nitrogen dioxide in the nitric-oxide releasing agent to nitric oxide gas by contacting the nitrogen dioxide with the reducing agent; and delivering the nitric oxide gas to the subject in a gas flow. - View Dependent Claims (2, 3, 4, 5)
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6. A method for delivering nitric oxide to a subject comprising:
introducing a nitric-oxide releasing agent in an air flow into a receptacle including an inlet, an outlet and a porous support coated with a reducing agent, wherein the reducing agent is selected from a group consisting of ascorbic acid, alpha tocopherol or gamma tocopherol, and wherein the nitric-oxide releasing agent includes nitrogen dioxide; converting the nitrogen dioxide in the nitric-oxide releasing agent to nitric oxide gas in the air flow by contacting the nitrogen dioxide with the reducing agent; and delivering the nitric oxide gas to the subject in a gas flow including the air flow. - View Dependent Claims (7, 8, 9, 10)
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