Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis

• US 8,609,082 B2
• Filed: 01/25/2006
• Issued: 12/17/2013
• Est. Priority Date: 01/25/2005
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: BioControl Medical (B.C.M) Ltd.
• Inventors: Ben-David, Tamir, Ben-Ezra, Omry, Cohen, Ehud
• Primary Examiner(s): Crouch, Deborah
• Assistant Examiner(s): Moloye, Titilayo
• Application Number:
  US11/340,156
• Publication Number:
  US 20060167501A1
• Time in Patent Office: 2,883 Days
• Field of Search: None
• US Class Current: 424/93.1
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/36121 Production of neurotransmitters; Modulation of genes expression
• CPC Class Codes: A61N 1/36157 Current A61N1/3616 takes precedence

Abstract

A method is provided including selecting a patient suffering from a condition, administering cells to the patient selected from the group consisting of: progenitor cells and genetically-modified cells, applying an electrical current to a site of the patient in a vicinity of nervous tissue, and configuring the current to stimulate the nervous tissue. Other embodiments are also described.

Claims

1. A method comprising:

selecting a patient suffering from a heart condition;

selecting cells capable of promoting function of a heart of the patient, the cells selected from the group consisting of;

bone marrow progenitor cells, genetically-modified bone marrow progenitor cells, and myoblasts;

administering the cells to the patient;

applying an electrical current to a site of the patient in a vicinity of parasympathetic nervous tissue, wherein applying the current comprises initiating application of the current before administering the cells, and applying the current only within 48 hours of a time of administering the cells; and

configuring the current to stimulate the parasympathetic nervous tissue to reduce arrhythmia that may be caused by administration of the cells, wherein cardiac repair is facilitated, blood supply is enhanced and/or angiogenesis is enhanced.

2. The method according to claim 1, wherein applying the current comprises applying the current to an epicardial fat pad.

3. The method according to claim 1, wherein applying the current comprises synchronizing application of the current with a cardiac cycle of the patient.

4. The method according to claim 3, wherein applying the current comprises applying the current during a refractory period of heart of the patient.

5. The method according to claim 1, wherein applying the current comprises applying the current with an amplitude less than a pacing threshold of the heart.

6. The method according to claim 1, wherein the cells are selected from the group consisting of:

skeletal myoblasts, and smooth muscle myoblasts, and wherein administering the cells comprises administering the selected myoblasts.

7. The method according to claim 1, wherein the site is selected from the group consisting of:

a carotid artery, a coronary body, a coronary sinus, a vena cava vein, and an internal jugular vein, and wherein applying the current to the site comprises applying the current to the selected site.

8. The method according to claim 1, wherein the site includes a portion of a vagus nerve that innervates the heart, and wherein applying the current comprises applying the current to the portion of the vagus nerve that innervates the heart.

9. The method according to claim 1, wherein configuring the current to stimulate the parasympathetic nervous tissue comprises setting the current to have an amplitude between 1 and 20 mA, and a frequency between 0.01 and 10 Hz.

10. A method comprising:

selecting a patient suffering from a heart condition;

selecting cells capable of promoting function of a heart of the patient, the cells selected from the group consisting of;

bone marrow progenitor cells , genetically-modified bone marrow progenitor cells, and myoblasts;

administering the cells to the patient;

applying an electrical current to a site of the patient in a vicinity of parasympathetic nervous tissue, wherein applying the current comprises initiating application of the current before administering the cells, and assessing, prior to administering the cells, a response of the patient to the application of the current, and modifying an administration parameter of the administration of the cells in response to the assessment; and

configuring the current to stimulate the parasympathetic nervous tissue to reduce arrhythmia that may be caused by administration of the cells,

wherein cardiac repair is facilitated, blood supply is enhanced and/or angiogenesis is enhanced.

11. The method according to claim 10, wherein applying the current comprises applying the current to an epicardial fat pad.

12. The method according to claim 10, wherein applying the current comprises synchronizing application of the current with a cardiac cycle of the patient.

13. The method according to claim 12, wherein applying the current comprises applying the current during a refractory period of heart of the patient.

14. The method according to claim 10, wherein applying the current comprises applying the current with an amplitude less than a pacing threshold of the heart.

15. The method according to claim 10, wherein the cells are selected from the group consisting of:

skeletal myoblasts, and smooth muscle myoblasts, and wherein administering the cells comprises administering the selected myoblasts.

16. The method according to claim 10, wherein the site is selected from the group consisting of:

a carotid artery, a coronary body, a coronary sinus, a vena cava vein, and an internal jugular vein, and wherein applying the current to the site comprises applying the current to the selected site.

17. The method according to claim 10, wherein the site includes a portion of a vagus nerve that innervates the heart, and wherein applying the current comprises applying the current to the portion of the vagus nerve that innervates the heart.

18. The method according to claim 10, wherein configuring the current to stimulate the parasympathetic nervous tissue comprises setting the current to have an amplitude between 1 and 20 mA, and a frequency between 0.01 and 10 Hz.