Immobilized bioactive hydrogel matrices as surface coatings
First Claim
1. A coated structural implant for providing improved integration with natural tissue, the coated structural implant comprising:
- a structural implant having a surface and being formed with a material suitable for repair of bone, ligament, or tendon; and
a bioactive hydrogel matrix layer overlying the surface of the structural implant and immobilized thereon, the hydrogel matrix layer being a solid or semi-solid material at physiological temperature and physiological pH and comprising a polyglycan, a polypeptide, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof, at least one of the polyglycan and the polypeptide being covalently cross-linked to the surface of the structural implant.
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Abstract
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
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Citations
29 Claims
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1. A coated structural implant for providing improved integration with natural tissue, the coated structural implant comprising:
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a structural implant having a surface and being formed with a material suitable for repair of bone, ligament, or tendon; and a bioactive hydrogel matrix layer overlying the surface of the structural implant and immobilized thereon, the hydrogel matrix layer being a solid or semi-solid material at physiological temperature and physiological pH and comprising a polyglycan, a polypeptide, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof, at least one of the polyglycan and the polypeptide being covalently cross-linked to the surface of the structural implant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 19)
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16. A coated structural implant for providing improved integration with natural tissue, the coated structural implant comprising:
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a structural implant having a surface and being formed with a material suitable for repair of bone, ligament, or tendon; and a bioactive hydrogel matrix layer overlying the surface of the structural implant and immobilized thereon, the hydrogel matrix layer being a solid or semi-solid material at physiological temperature and physiological pH and comprising a polyglycan and a polypeptide, wherein at least one of the polyglycan and polypeptide is covalently cross-linked to the surface of the structural implant, wherein the polyglycan is dextran or oxidized dextran and the polypeptide is gelatin. - View Dependent Claims (17, 18, 20, 21, 22, 23, 24)
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25. A coated structural implant for providing improved integration with natural tissue, the coated structural implant comprising:
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a structural implant having a surface and being selected from the group consisting of ligament replacements, bone replacements, tendon replacements, and joint replacements; and a bioactive hydrogel matrix layer overlying the surface of the structural implant and immobilized thereon, the hydrogel matrix layer being a solid or semi-solid material at physiological temperature and physiological pH and comprising a polyglycan and a polypeptide; wherein the structural implant is formed with a material selected from the group consisting of acrylates, polyglycolic-polylactic acid copolymers, polyhydroxybutyrates, polyesters, expanded polytetrafluoroethylene, bioactive glass, ceramics, coralline materials, demineralized bone, polycarbonates, polyurethane or polycarbonate copolymers, metals, and combinations thereof, wherein the polyglycan is dextran or oxidized dextran and the polypeptide is gelatin. - View Dependent Claims (26, 27, 28, 29)
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Specification