Detection of methylated DNA and DNA mutations
First Claim
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1. A method of preparing a nanosensor to detect DNA methylation, comprising:
- providing a nanosensor; and
attaching a probe to the nanosensor,wherein the probe is adapted to bind a methylated DNA sequence and an agent,wherein the nanosensor is configured to detectably change in conductance when the methylated DNA sequence is itself bound by the agent.
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Abstract
The present invention relates to various methods of detecting DNA methylation and defected DNA. In one embodiment, the invention provides a nanosensor bound to a probe that is complementary to a DNA methylation sequence.
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Citations
8 Claims
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1. A method of preparing a nanosensor to detect DNA methylation, comprising:
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providing a nanosensor; and attaching a probe to the nanosensor, wherein the probe is adapted to bind a methylated DNA sequence and an agent, wherein the nanosensor is configured to detectably change in conductance when the methylated DNA sequence is itself bound by the agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification