Apparatus and method for maintaining and/or restoring viability of organs
First Claim
1. A system for holding an organ during perfusion, storage and transport of the organ, comprising:
- an organ cassette for holding the organ, the organ cassette includingan organ supporting surface that supports the organ, andtwo lids connected or connectable to the organ cassette;
each of the two lids individually forming a substantially airtight seal with the organ cassette;
a perfusion circuit configured to provide recirculating perfusion for the organ;
a transporter having a compartment structured to receive and support the organ cassette, the transporter being a portable organ perfusion apparatus,wherein the organ cassette is configured (1) to hold the organ independently from the transporter, (2) to be received by the transporter, without jeopardizing sterility of an interior of the organ cassette, for transport of the organ, (3) to be removed from the transporter without jeopardizing sterility of the interior of the organ cassette and without removal of the organ from the organ cassette, and (4) to allow the recirculating perfusion, storage, and transport of the organ without removal of the organ from the organ cassette.
1 Assignment
0 Petitions
Accused Products
Abstract
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
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Citations
25 Claims
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1. A system for holding an organ during perfusion, storage and transport of the organ, comprising:
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an organ cassette for holding the organ, the organ cassette including an organ supporting surface that supports the organ, and two lids connected or connectable to the organ cassette; each of the two lids individually forming a substantially airtight seal with the organ cassette; a perfusion circuit configured to provide recirculating perfusion for the organ; a transporter having a compartment structured to receive and support the organ cassette, the transporter being a portable organ perfusion apparatus, wherein the organ cassette is configured (1) to hold the organ independently from the transporter, (2) to be received by the transporter, without jeopardizing sterility of an interior of the organ cassette, for transport of the organ, (3) to be removed from the transporter without jeopardizing sterility of the interior of the organ cassette and without removal of the organ from the organ cassette, and (4) to allow the recirculating perfusion, storage, and transport of the organ without removal of the organ from the organ cassette. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 22, 23, 24)
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18. A system for holding an organ during perfusion, storage and transport of the organ, comprising:
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a portable housing for holding the organ, the portable housing including two lids connected or connectable to the portable housing; each of the two lids individually forming a substantially airtight seal with the portable housing; a perfusion circuit configured to provide recirculating perfusion for the organ; an organ perfusion apparatus adapted to receive the portable housing; and a transporter adapted to receive the portable housing, the transporter being a portable organ perfusion apparatus, wherein the organ perfusion apparatus and the transporter are separate units and the portable housing is configured (1) to hold the organ independently from either of the organ perfusion apparatus or the transporter, (2) to be received by the transporter for transport of the organ without jeopardizing sterility of an interior of the portable housing, (3) to be separately received by the organ perfusion apparatus, without jeopardizing sterility of the interior of the portable housing, for perfusion of the organ, and (4) to allow the recirculating perfusion, storage, and transport of the organ without removal of the organ from the portable housing. - View Dependent Claims (19)
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25. A system for holding an organ during perfusion, storage and transport of the organ, comprising:
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an organ cassette for holding the organ, the organ cassette including; an organ supporting surface that supports the organ, and a first lid and a second lid connected or connectable to the organ cassette; the first lid and the second lid each having a port configured to allow access to the organ; the ports in the first lid and the second lid being aligned substantially along a vertical line; a perfusion circuit configured to provide recirculating perfusion for the organ; a transporter having a compartment structured to receive and support the organ cassette, the transporter being a portable organ perfusion apparatus, wherein the organ cassette is configured (1) to hold the organ independently from the transporter, (2) to be received by the transporter, without jeopardizing sterility of an interior of the organ cassette, for transport of the organ, (3) to be removed from the transporter without jeopardizing sterility of the interior of the organ cassette and without removal of the organ from the organ cassette, and (4) to allow the recirculating perfusion, storage, and transport of the organ without removal of the organ from the organ cassette.
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Specification