Pharmaceutical formulation

• US 8,609,645 B2
• Filed: 11/10/2011
• Issued: 12/17/2013
• Est. Priority Date: 08/13/2004
• Status: Active Grant

• Current Assignee: Intervet Incorporated (Merck & Co., Inc.)
• Original Assignee: Intervet Incorporated (Merck & Co., Inc.)
• Inventors: Huq, Abu S., Weingarten, Allan J., Simmons, Robert D.
• Primary Examiner(s): Claytor, Renee
• Assistant Examiner(s): Javanmard, Sahar
• Application Number:
  US13/293,994
• Publication Number:
  US 20120058964A1
• Time in Patent Office: 768 Days
• Field of Search: 514/171, 514/253.08, 514/254.07, 514/297, 514/397
• US Class Current: 514/171
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/4174 Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
• CPC Class Codes: A61K 31/4178 not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/538 ortho- or peri-condensed with carbocyclic ring systems
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a corticosteroid such as mometasone furoate monohydrate.

Claims

1. A pharmaceutical composition for the treatment of an otic infection in an animal comprising Orbifloxacin or one of its pharmaceutically acceptable salts in an amount of about 0.1% to about 10% by weight, Posaconazole in an amount of about 0.01% to about 1% by weight, Mometasone in an amount of about 0.01% to about 1% by weight, a viscocity enhancing agent in an amount of about 0.1% to about 5% by weight, and at least one pharmaceutically acceptable carrier, wherein said composition is a suspension.

2. The composition according to claim 1, wherein the viscosity enhancing agent is selected from the group consisting of methylcellulose, water soluble salts of cellulose ethers, carboxymethyl hydroxyethyl cellulose, hydroxyethyl cellulose, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate, carbomer, providone, acacia, guar gum, xanthan gum, gum karaya, gum arabic, gum tragacanth, magnesium aluminum silicate, carboxyvinyl polymers, carrageenen, laponite, and mineral oil with polyethylene.

3. The composition according to claim 1, wherein about 1% of the composition is Orbifloxacin.

4. The composition according to claim 1, wherein about 0.1 wt % of the composition is Posaconazole.