Portable orthovoltage radiotherapy

• US 8,611,497 B2
• Filed: 11/14/2011
• Issued: 12/17/2013
• Est. Priority Date: 10/16/2006
• Status: Active Grant

• Current Assignee: Carl Zeiss Meditec Incorporated (Carl-Zeiss-Stiftung)
• Original Assignee: Oraya Therapeutics, Inc.
• Inventors: Gertner, Michael
• Primary Examiner(s): Midkiff, Anastasia
• Application Number:
  US13/296,094
• Publication Number:
  US 20120057675A1
• Time in Patent Office: 764 Days
• Field of Search: 378/65, 378/68, 606 1- 6, 606/10, 606/13, 606/17, 606/107, 606/130, 600/1, 600/2, 600/407, 600425-429, 604/19, 604/20
• US Class Current: 378/65
• CPC Class Codes: A61B 2017/306 holding by means of suction
• CPC Class Codes: A61B 6/506 for diagnosis of nerves
• CPC Class Codes: A61F 9/009 Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses apparatus for eye examination A61B3/0008
• CPC Class Codes: A61N 2005/105 using a laser alignment system
• CPC Class Codes: A61N 2005/1056 by projecting a visible image of the treatment field
• CPC Class Codes: A61N 2005/1091 Kilovoltage or orthovoltage range photons
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam

Abstract

A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.

Claims

1. A method, of applying radiation to a patient'"'"'s eye, comprising:

identifying (i) a fiducial marker location on an eye contact member that contacts an outer surface of the eye, and (ii) a mapped location, based on imaging data, of a target region within the eye relative to the marker location;

positioning, based on the mapped location, a source that emits x-ray radiation; and

emitting the radiation from the source to the target region.

2. The method of claim 1, wherein the target region comprises a macula of the eye.

3. The method of claim 1, further comprising determining the mapped location by mapping a location of the target region in a coordinate system.

4. The method of claim 3, further comprising, after mapping the location of the target region, detecting a movement of the eye.

5. The method of claim 4, further comprising determining a relative relationship between a new location of the target region and the mapped location in the coordinate system after the detecting the eye movement.

6. The method of claim 1, further comprising collimating the emitted radiation to a radiation beam having a cross-sectional width of less than about 6 mm.

7. The method of claim 1, further comprising repositioning the source based on a movement of the fiducial marker location to a second fiducial marker location.

8. The method of claim 7, further comprising after the repositioning of the source, emitting an additional radiation beam from the source to the target region.

9. The method of claim 1, wherein the emitting the radiation comprises emitting radiation toward a region of drusen in the eye.

10. The method of claim 1, wherein the emitting the radiation comprises emitting an x-ray beam.

11. The method of claim 10, further comprising applying at least one additional radiation beam to the target region.

12. The method of claim 11, wherein the x-ray beam and the at least one additional radiation beam are applied simultaneously.

13. The method of claim 1, wherein the imaging data is obtained with at least one of computed tomography, magnetic resonance imaging, optical coherence tomography, and positron emission tomography.

14. The method of claim 1, further comprising obtaining the imaging data of at least a portion of the eye.

15. A method, of applying radiation to a patient'"'"'s eye, comprising:

positioning a radiation source based on a relative position between (i) a mapped location, in a coordinate system and determined from imaging data, of a target region within an eye and (ii) a fiducial marker location on a contact member that contacts an outer surface of the eye; and

emitting x-ray radiation from the source toward the target region within the eye.

16. The method of claim 15, wherein the target region comprises a macula of the eye.

17. The method of claim 15, wherein the mapped location comprises a location of the macula, relative to the fiducial marker location, thereby producing a mapped macula location in the coordinate system.

18. The method of claim 17, further comprising, after mapping the location of the macula, detecting a movement of the eye.

19. The method of claim 18, further comprising determining a relative relationship between a new location of the macula and the mapped macula location in the coordinate system after the detecting the eye movement.

20. The method of claim 15, further comprising applying at least one additional radiation beam to the target region.

21. The method of claim 20, wherein the x-ray radiation and the at least one additional radiation beam are applied simultaneously.

22. The method of claim 15, further comprising collimating the emitted radiation to a radiation beam having a cross-sectional width of less than about 6 mm.